Taxel_therapies less effective in the TP53+ biomarker signature
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.164, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 6, median = 4.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.68, hr = 1.5 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 4.5, median = 3.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.52, hr = 2 | af = 1, hr = 1 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.164, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 6, median = 4.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.68, hr = 1.5 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.164, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 6, median = 4.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.68, hr = 1.5 | af = 1, hr = 1 | af = 1, hr = 1 |
|
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The overall error was 0.44.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.226 0.062 0.082 0.140
The overall power was .
The corresponding power separate for the different treatments were:
NULL
| signature | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| all | graduation | 2 | 0 | 20 | 2 | 0 |
| futility | 1 | 0 | 3 | 0 | 23 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 207 (151, 270) | 434 (401, 467) | 197 (131, 270) | 202 (145, 269) | 135 (94, 199) | |
| n_unique | 189 (136, 249) | 392 (362, 424) | 180 (119, 251) | 185 (129, 247) | 123 (85, 184) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 8 (7, 22) | NA (NA, NA) | 5 (3, 6) | 6 (6, 6) | 20 (5, 34) | |
| post_p | 0.84 (0.37, 0.99) | NA (NA, NA) | 0.82 (0.33, 0.99) | 0.83 (0.36, 0.99) | 0.2 (0.01, 0.74) | |
| rate | 0.112 (0.102, 0.124) | 0.123 (0.115, 0.132) | 0.112 (0.102, 0.126) | 0.112 (0.101, 0.125) | 0.134 (0.119, 0.164) | |
| DRD+ | graduation | 8 | 0 | 6 | 6 | 0 |
| futility | 10 | 0 | 9 | 5 | 60 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 68 (47, 90) | 118 (102, 134) | 47 (26, 68) | 65 (44, 86) | 38 (23, 57) | |
| n_unique | 62 (41, 82) | 105 (91, 120) | 42 (23, 62) | 58 (40, 78) | 34 (20, 52) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (34, 36) | |
| time_stop | 13 (9, 26) | NA (NA, NA) | 24 (15, 33) | 16 (9, 22) | 29 (22, 34) | |
| post_p | 0.72 (0.26, 0.96) | NA (NA, NA) | 0.64 (0.19, 0.94) | 0.69 (0.23, 0.96) | 0.31 (0.04, 0.79) | |
| rate | 0.111 (0.095, 0.134) | 0.123 (0.107, 0.14) | 0.113 (0.093, 0.144) | 0.113 (0.095, 0.139) | 0.136 (0.107, 0.19) | |
| TEfus+ | graduation | 3 | 0 | 9 | 11 | 0 |
| futility | 8 | 0 | 3 | 5 | 106 | |
| max_n | 1 | 0 | 0 | 0 | 0 | |
| n | 80 (55, 107) | 159 (138, 177) | 73 (40, 100) | 78 (49, 108) | 52 (29, 74) | |
| n_unique | 71 (49, 98) | 143 (125, 160) | 66 (35, 91) | 70 (44, 98) | 47 (27, 67) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (20, 36) | |
| time_stop | 17 (11, 31) | NA (NA, NA) | 18 (11, 30) | 16 (10, 26) | 21 (12, 32) | |
| post_p | 0.74 (0.28, 0.97) | NA (NA, NA) | 0.75 (0.27, 0.98) | 0.75 (0.27, 0.98) | 0.21 (0.01, 0.71) | |
| rate | 0.113 (0.096, 0.134) | 0.125 (0.11, 0.141) | 0.113 (0.093, 0.134) | 0.113 (0.096, 0.135) | 0.145 (0.116, 0.187) | |
| TP53- & AR- | graduation | 22 | 0 | 56 | 32 | 31 |
| futility | 109 | 0 | 145 | 131 | 121 | |
| max_n | 17 | 0 | 23 | 12 | 12 | |
| n | 73 (29, 128) | 178 (153, 204) | 64 (25, 133) | 66 (26, 125) | 65 (26, 124) | |
| n_unique | 66 (26, 120) | 163 (138, 186) | 59 (24, 128) | 60 (24, 117) | 60 (24, 117) | |
| time_trial | 36 (17, 36) | 36 (36, 36) | 36 (9, 36) | 36 (16, 36) | 36 (16, 36) | |
| time_stop | 20 (13, 31) | NA (NA, NA) | 12 (7, 27) | 21 (11, 31) | 20 (12, 31) | |
| post_p | 0.48 (0.1, 0.88) | NA (NA, NA) | 0.49 (0.07, 0.89) | 0.5 (0.1, 0.9) | 0.44 (0.08, 0.9) | |
| rate | 0.114 (0.098, 0.14) | 0.113 (0.1, 0.127) | 0.114 (0.097, 0.143) | 0.114 (0.094, 0.145) | 0.115 (0.098, 0.146) | |
| TP53+ | graduation | 12 | 0 | 34 | 29 | 0 |
| futility | 3 | 0 | 4 | 1 | 366 | |
| max_n | 38 | 0 | 23 | 28 | 0 | |
| n | 102 (69, 143) | 192 (173, 216) | 103 (39, 139) | 102 (68, 140) | 37 (25, 55) | |
| n_unique | 92 (61, 131) | 173 (154, 196) | 94 (35, 128) | 93 (61, 130) | 33 (23, 51) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 25 (12, 36) | |
| time_stop | 12 (9, 30) | NA (NA, NA) | 10 (8, 19) | 13 (8, 32) | 20 (11, 32) | |
| post_p | 0.94 (0.54, 1) | NA (NA, NA) | 0.93 (0.55, 1) | 0.93 (0.59, 1) | 0.01 (0, 0.06) | |
| rate | 0.112 (0.098, 0.133) | 0.139 (0.124, 0.153) | 0.112 (0.097, 0.131) | 0.113 (0.096, 0.13) | 0.226 (0.186, 0.293) |
| subtype | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| —- | graduation | 134 | 0 | 223 | 165 | 164 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 17 | 0 | 23 | 12 | 12 | |
| n | 36 (9, 91) | 114 (93, 133) | 35 (17, 100) | 34 (9, 87) | 34 (10, 92) | |
| n_unique | 34 (8, 85) | 104 (85, 124) | 33 (16, 95) | 32 (8, 82) | 32 (8, 86) | |
| post_p | 0.42 (0.08, 0.89) | NA (NA, NA) | 0.45 (0.1, 0.9) | 0.43 (0.1, 0.89) | 0.39 (0.1, 0.89) | |
| rate | 0.117 (0.093, 0.19) | 0.113 (0.097, 0.13) | 0.117 (0.094, 0.157) | 0.117 (0.093, 0.185) | 0.121 (0.094, 0.187) | |
| —+ | graduation | 139 | 0 | 231 | 178 | 219 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 18 | 0 | 23 | 12 | 12 | |
| n | 7 (2, 20) | 22 (15, 29) | 7 (2, 20) | 7 (2, 19) | 8 (3, 21) | |
| n_unique | 7 (2, 18) | 20 (14, 27) | 6 (2, 18) | 6 (2, 17) | 8 (2, 19) | |
| post_p | 0.46 (0.18, 0.85) | NA (NA, NA) | 0.46 (0.18, 0.83) | 0.48 (0.18, 0.86) | 0.46 (0.16, 0.83) | |
| rate | 0.127 (0.075, 0.325) | 0.115 (0.085, 0.157) | 0.128 (0.075, 0.31) | 0.123 (0.073, 0.328) | 0.127 (0.081, 0.319) | |
| –+- | graduation | 17 | 0 | 60 | 32 | 375 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 38 | 0 | 23 | 28 | 0 | |
| n | 32 (8, 59) | 64 (52, 78) | 37 (10, 63) | 33 (8, 59) | 7 (4, 15) | |
| n_unique | 29 (7, 55) | 57 (46, 72) | 34 (10, 59) | 30 (7, 54) | 7 (3, 14) | |
| post_p | 0.76 (0.22, 0.98) | NA (NA, NA) | 0.78 (0.26, 0.98) | 0.74 (0.22, 0.98) | 0.16 (0.06, 0.36) | |
| rate | 0.116 (0.089, 0.21) | 0.14 (0.116, 0.164) | 0.116 (0.091, 0.169) | 0.117 (0.09, 0.187) | 0.252 (0.165, 0.451) | |
| –++ | graduation | 28 | 0 | 69 | 44 | 399 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 39 | 0 | 23 | 28 | 0 | |
| n | 21 (5, 38) | 44 (34, 54) | 23 (5, 41) | 20 (5, 37) | 8 (5, 15) | |
| n_unique | 18 (4, 35) | 40 (30, 50) | 21 (4, 38) | 18 (5, 35) | 8 (4, 14) | |
| post_p | 0.66 (0.21, 0.96) | NA (NA, NA) | 0.72 (0.24, 0.97) | 0.71 (0.24, 0.96) | 0.14 (0.04, 0.37) | |
| rate | 0.121 (0.085, 0.243) | 0.139 (0.113, 0.173) | 0.115 (0.087, 0.203) | 0.117 (0.085, 0.2) | 0.246 (0.169, 0.476) | |
| -+– | graduation | 149 | 0 | 227 | 167 | 198 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 17 | 0 | 23 | 12 | 12 | |
| n | 11 (3, 23) | 21 (15, 28) | 5 (0, 16) | 9 (3, 19) | 7 (2, 19) | |
| n_unique | 10 (3, 21) | 19 (13, 25) | 4 (0, 14) | 8 (2, 18) | 6 (2, 17) | |
| post_p | 0.47 (0.17, 0.86) | NA (NA, NA) | 0.45 (0.18, 0.81) | 0.46 (0.18, 0.8) | 0.45 (0.17, 0.84) | |
| rate | 0.119 (0.081, 0.251) | 0.115 (0.08, 0.157) | 0.126 (0.075, 0.384) | 0.125 (0.08, 0.278) | 0.122 (0.077, 0.336) | |
| -+-+ | graduation | 153 | 0 | 235 | 179 | 245 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 18 | 0 | 23 | 12 | 12 | |
| n | 10 (3, 23) | 21 (15, 28) | 5 (0, 18) | 9 (3, 21) | 6 (2, 18) | |
| n_unique | 9 (3, 20) | 19 (13, 26) | 4 (0, 16) | 8 (3, 19) | 6 (1, 16) | |
| post_p | 0.45 (0.17, 0.83) | NA (NA, NA) | 0.44 (0.19, 0.83) | 0.47 (0.17, 0.87) | 0.42 (0.18, 0.84) | |
| rate | 0.126 (0.078, 0.234) | 0.112 (0.082, 0.161) | 0.126 (0.071, 0.319) | 0.12 (0.079, 0.26) | 0.132 (0.079, 0.32) | |
| -++- | graduation | 32 | 0 | 75 | 42 | 382 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 38 | 0 | 23 | 28 | 0 | |
| n | 7 (2, 13) | 13 (8, 18) | 5 (1, 12) | 7 (2, 15) | 2 (0, 6) | |
| n_unique | 6 (2, 12) | 11 (7, 16) | 4 (1, 11) | 6 (2, 14) | 2 (0, 5) | |
| post_p | 0.59 (0.26, 0.88) | NA (NA, NA) | 0.55 (0.24, 0.9) | 0.6 (0.25, 0.92) | 0.32 (0.17, 0.51) | |
| rate | 0.128 (0.066, 0.326) | 0.141 (0.09, 0.23) | 0.125 (0.065, 0.37) | 0.123 (0.071, 0.313) | 0.29 (0.141, 0.876) | |
| -+++ | graduation | 41 | 0 | 82 | 54 | 404 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 39 | 0 | 23 | 28 | 0 | |
| n | 7 (2, 14) | 13 (8, 18) | 5 (1, 11) | 7 (2, 15) | 2 (1, 5) | |
| n_unique | 6 (2, 13) | 11 (7, 16) | 4 (1, 10) | 6 (2, 14) | 2 (0, 5) | |
| post_p | 0.56 (0.25, 0.91) | NA (NA, NA) | 0.54 (0.24, 0.87) | 0.54 (0.25, 0.88) | 0.33 (0.18, 0.5) | |
| rate | 0.124 (0.071, 0.36) | 0.136 (0.09, 0.225) | 0.134 (0.064, 0.375) | 0.131 (0.076, 0.3) | 0.282 (0.139, 1.075) | |
| +— | graduation | 3 | 0 | 23 | 2 | 23 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (3, 18) | 20 (15, 28) | 8 (2, 19) | 8 (3, 18) | 11 (4, 21) | |
| n_unique | 7 (2, 16) | 18 (13, 26) | 8 (2, 18) | 7 (2, 16) | 10 (3, 19) | |
| post_p | 0.46 (0.17, 0.83) | NA (NA, NA) | 0.48 (0.17, 0.86) | 0.45 (0.19, 0.83) | 0.48 (0.18, 0.86) | |
| rate | 0.126 (0.077, 0.348) | 0.115 (0.085, 0.162) | 0.125 (0.079, 0.315) | 0.129 (0.077, 0.319) | 0.121 (0.082, 0.259) | |
| +–+ | graduation | 14 | 0 | 35 | 18 | 115 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 1 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 14) | 16 (10, 23) | 6 (2, 14) | 6 (2, 15) | 8 (3, 17) | |
| n_unique | 5 (2, 13) | 14 (9, 21) | 5 (1, 13) | 6 (2, 13) | 8 (2, 16) | |
| post_p | 0.46 (0.21, 0.81) | NA (NA, NA) | 0.42 (0.18, 0.82) | 0.46 (0.19, 0.84) | 0.46 (0.18, 0.87) | |
| rate | 0.126 (0.074, 0.366) | 0.113 (0.08, 0.168) | 0.135 (0.074, 0.408) | 0.124 (0.071, 0.362) | 0.123 (0.074, 0.306) | |
| +-+- | graduation | 17 | 0 | 60 | 32 | 375 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 38 | 0 | 23 | 28 | 0 | |
| n | 8 (3, 17) | 17 (12, 23) | 7 (2, 17) | 8 (2, 17) | 4 (2, 9) | |
| n_unique | 7 (2, 16) | 15 (10, 21) | 6 (1, 15) | 7 (2, 16) | 4 (2, 9) | |
| post_p | 0.59 (0.25, 0.92) | NA (NA, NA) | 0.56 (0.27, 0.89) | 0.61 (0.26, 0.92) | 0.26 (0.11, 0.48) | |
| rate | 0.125 (0.077, 0.33) | 0.139 (0.099, 0.211) | 0.127 (0.08, 0.293) | 0.118 (0.069, 0.281) | 0.258 (0.153, 0.68) | |
| +-++ | graduation | 28 | 0 | 69 | 44 | 399 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 39 | 0 | 23 | 28 | 0 | |
| n | 8 (2, 17) | 17 (11, 23) | 7 (2, 16) | 8 (2, 17) | 4 (2, 8) | |
| n_unique | 7 (2, 15) | 15 (10, 21) | 6 (1, 15) | 7 (2, 15) | 4 (1, 8) | |
| post_p | 0.57 (0.24, 0.93) | NA (NA, NA) | 0.6 (0.24, 0.92) | 0.57 (0.24, 0.92) | 0.27 (0.12, 0.49) | |
| rate | 0.122 (0.071, 0.376) | 0.138 (0.099, 0.208) | 0.124 (0.074, 0.353) | 0.122 (0.073, 0.308) | 0.248 (0.152, 0.716) | |
| ++– | graduation | 21 | 0 | 38 | 13 | 77 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 13) | 12 (7, 17) | 4 (1, 10) | 6 (2, 12) | 5 (2, 10) | |
| n_unique | 6 (2, 12) | 10 (6, 15) | 4 (1, 9) | 5 (2, 11) | 4 (1, 9) | |
| post_p | 0.49 (0.22, 0.83) | NA (NA, NA) | 0.45 (0.2, 0.8) | 0.47 (0.2, 0.84) | 0.46 (0.21, 0.82) | |
| rate | 0.12 (0.073, 0.326) | 0.115 (0.074, 0.18) | 0.134 (0.068, 0.461) | 0.122 (0.073, 0.371) | 0.127 (0.066, 0.419) | |
| ++-+ | graduation | 30 | 0 | 48 | 28 | 153 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 1 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 13) | 12 (8, 18) | 5 (1, 10) | 6 (2, 13) | 5 (1, 11) | |
| n_unique | 5 (2, 12) | 11 (6, 16) | 4 (1, 9) | 5 (2, 12) | 4 (1, 10) | |
| post_p | 0.46 (0.19, 0.82) | NA (NA, NA) | 0.45 (0.21, 0.8) | 0.45 (0.18, 0.82) | 0.44 (0.22, 0.83) | |
| rate | 0.128 (0.068, 0.324) | 0.113 (0.076, 0.179) | 0.132 (0.064, 0.432) | 0.132 (0.072, 0.361) | 0.126 (0.065, 0.435) | |
| +++- | graduation | 32 | 0 | 75 | 42 | 382 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 38 | 0 | 23 | 28 | 0 | |
| n | 7 (2, 15) | 12 (8, 18) | 4 (1, 11) | 7 (2, 14) | 2 (1, 6) | |
| n_unique | 7 (2, 14) | 11 (7, 16) | 4 (1, 10) | 7 (2, 14) | 2 (0, 5) | |
| post_p | 0.61 (0.26, 0.92) | NA (NA, NA) | 0.58 (0.26, 0.89) | 0.62 (0.26, 0.91) | 0.34 (0.19, 0.5) | |
| rate | 0.128 (0.072, 0.351) | 0.145 (0.096, 0.233) | 0.126 (0.068, 0.354) | 0.122 (0.073, 0.344) | 0.263 (0.139, 1.024) | |
| ++++ | graduation | 41 | 0 | 82 | 54 | 404 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 39 | 0 | 23 | 28 | 0 | |
| n | 8 (2, 14) | 13 (8, 18) | 5 (1, 11) | 6 (2, 13) | 2 (0, 5) | |
| n_unique | 7 (2, 13) | 11 (7, 16) | 4 (1, 10) | 5 (2, 12) | 2 (0, 5) | |
| post_p | 0.57 (0.27, 0.91) | NA (NA, NA) | 0.54 (0.27, 0.88) | 0.56 (0.25, 0.89) | 0.32 (0.2, 0.51) | |
| rate | 0.123 (0.073, 0.354) | 0.141 (0.092, 0.212) | 0.125 (0.068, 0.418) | 0.127 (0.074, 0.342) | 0.274 (0.143, 1.106) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Carboplatin | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|
| all | count | 20 | 2 | 2 | |
| time_stop | 5 (3, 6) | 16 (9, 24) | 6 (6, 6) | ||
| n_trt | 32 (26, 46) | 106 (54, 159) | 26 (25, 26) | ||
| n_control | 54 (42, 69) | 190 (96, 283) | 68 (66, 70) | ||
| post_p | 0.92 (0.87, 0.97) | 0.99 (0.98, 0.99) | 0.94 (0.92, 0.96) | ||
| order | 1 (1, 1) | 1.5 (1.1, 1.9) | 1 (1, 1) | ||
| TP53- & AR- | count | 56 | 22 | 32 | 31 |
| time_stop | 10 (7, 20) | 15 (12, 31) | 15 (10, 26) | 13 (9, 24) | |
| n_trt | 32 (26, 68) | 40 (27, 100) | 38 (26, 71) | 32 (26, 63) | |
| n_control | 48 (30, 87) | 69 (49, 153) | 64 (43, 121) | 60 (43, 108) | |
| post_p | 0.91 (0.86, 0.96) | 0.94 (0.86, 0.98) | 0.95 (0.88, 0.99) | 0.92 (0.87, 0.98) | |
| order | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | |
| TP53+ | count | 34 | 12 | 29 | |
| time_stop | 10 (8, 20) | 12 (9, 27) | 13 (8, 32) | ||
| n_trt | 32 (26, 67) | 32 (25, 78) | 36 (26, 96) | ||
| n_control | 46 (33, 93) | 54 (37, 128) | 67 (35, 157) | ||
| post_p | 0.97 (0.88, 1) | 0.99 (0.96, 1) | 0.99 (0.94, 1) | ||
| order | 1 (1, 2) | 1 (1, 1.9) | 1 (1, 2.2) | ||
| DRD+ | count | 6 | 8 | 6 | |
| time_stop | 16 (14, 22) | 11 (10, 14) | 12 (8, 16) | ||
| n_trt | 26 (25, 37) | 26 (26, 33) | 28 (25, 36) | ||
| n_control | 50 (35, 64) | 30 (21, 41) | 32 (22, 52) | ||
| post_p | 0.99 (0.97, 1) | 0.95 (0.87, 0.98) | 0.97 (0.94, 0.98) | ||
| order | 1 (1, 3) | 1 (1, 2) | 2 (1, 3) | ||
| TEfus+ | count | 9 | 3 | 11 | |
| time_stop | 16 (12, 31) | 11 (10, 13) | 12 (10, 17) | ||
| n_trt | 35 (26, 72) | 27 (25, 33) | 29 (25, 48) | ||
| n_control | 56 (37, 152) | 42 (39, 49) | 46 (29, 63) | ||
| post_p | 0.99 (0.94, 1) | 0.98 (0.94, 1) | 0.95 (0.92, 0.99) | ||
| order | 2 (1, 3) | 2 (1.2, 2.8) | 1 (1, 1) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 3 | 23 | 1 | |
| time_stop | 4 (4, 5) | 20 (5, 34) | 8 (8, 8) | ||
| n_trt | 27 (26, 33) | 65 (27, 119) | 29 (29, 29) | ||
| n_control | 48 (47, 54) | 218 (56, 426) | 83 (83, 83) | ||
| post_p | 0.26 (0.13, 0.28) | 0 (0, 0.05) | 0.02 (0.02, 0.02) | ||
| order | 1 (1, 1) | 2 (1, 5.8) | 1 (1, 1) | ||
| TP53- & AR- | count | 145 | 121 | 109 | 131 |
| time_stop | 13 (7, 28) | 21 (13, 31) | 21 (13, 31) | 23 (13, 31) | |
| n_trt | 30 (25, 65) | 36 (25, 78) | 35 (25, 73) | 33 (25, 75) | |
| n_control | 60 (31, 133) | 101 (57, 161) | 90 (59, 143) | 101 (58, 156) | |
| post_p | 0.18 (0.04, 0.28) | 0.16 (0.04, 0.26) | 0.14 (0.04, 0.27) | 0.13 (0.03, 0.27) | |
| order | 1 (1, 2) | 2 (1, 3) | 2 (1, 3.2) | 2 (1, 3) | |
| TP53+ | count | 4 | 366 | 3 | 1 |
| time_stop | 11 (9, 12) | 20 (11, 32) | 17 (15, 28) | 20 (20, 20) | |
| n_trt | 30 (28, 31) | 33 (25, 47) | 34 (30, 44) | 32 (32, 32) | |
| n_control | 50 (36, 63) | 100 (48, 169) | 80 (76, 147) | 101 (101, 101) | |
| post_p | 0.19 (0.04, 0.27) | 0.01 (0, 0.08) | 0.12 (0.08, 0.16) | 0.08 (0.08, 0.08) | |
| order | 1.5 (1, 2) | 1 (1, 3) | 2 (1.2, 3.6) | 4 (4, 4) | |
| DRD+ | count | 9 | 60 | 10 | 5 |
| time_stop | 30 (23, 34) | 29 (22, 34) | 16 (8, 28) | 21 (17, 28) | |
| n_trt | 34 (28, 44) | 29 (25, 39) | 30 (25, 46) | 31 (27, 56) | |
| n_control | 100 (69, 115) | 85 (59, 115) | 46 (17, 74) | 64 (46, 99) | |
| post_p | 0.05 (0.02, 0.16) | 0.06 (0.01, 0.2) | 0.07 (0.03, 0.14) | 0.01 (0.01, 0.09) | |
| order | 3 (2, 4) | 3 (2, 4.1) | 1.5 (1, 3.1) | 4 (2.4, 4) | |
| TEfus+ | count | 3 | 106 | 8 | 5 |
| time_stop | 26 (14, 29) | 21 (12, 32) | 21 (15, 32) | 26 (18, 32) | |
| n_trt | 34 (28, 44) | 33 (26, 52) | 34 (26, 50) | 42 (27, 67) | |
| n_control | 112 (54, 117) | 80 (44, 144) | 100 (61, 141) | 107 (66, 152) | |
| post_p | 0.1 (0.03, 0.22) | 0.03 (0, 0.16) | 0.06 (0.02, 0.19) | 0.08 (0.02, 0.14) | |
| order | 2 (1.2, 4.4) | 2 (1, 4) | 3 (1.7, 4) | 2 (1.4, 4.2) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| time | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | 16 (9, 24) | ||
| n | 26 (9, 44) | 4 (2, 5) | 16 (7, 24) | 6 (3, 9) | 10 (5, 15) | 7 (1, 13) | 2 (2, 3) | 6 (5, 7) | 2 (2, 3) | 3 (1, 5) | 8 (6, 10) | 2 (1, 3) | 3 (3, 3) | 6 (3, 10) | 3 (1, 5) | 2 (1, 2) | ||
| post_p | 0.66 (0.56, 0.76) | 0.54 (0.52, 0.56) | 0.78 (0.64, 0.92) | 0.69 (0.57, 0.82) | 0.63 (0.58, 0.68) | 0.6 (0.6, 0.6) | 0.62 (0.58, 0.65) | 0.66 (0.6, 0.72) | 0.56 (0.56, 0.57) | 0.61 (0.61, 0.61) | 0.68 (0.59, 0.77) | 0.59 (0.58, 0.6) | 0.61 (0.53, 0.69) | 0.72 (0.64, 0.79) | 0.6 (0.56, 0.64) | 0.64 (0.64, 0.65) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.093 (0.09, 0.096) | 0.048 (0.01, 0.087) | 0.089 (0.088, 0.09) | 0.043 (0.009, 0.078) | 0.128 (0.101, 0.156) | 0.109 (0.109, 0.109) | 0.049 (0.01, 0.088) | 0.064 (0.051, 0.077) | 0.052 (0.01, 0.094) | 0.076 (0.076, 0.076) | 0.068 (0.014, 0.122) | 0.048 (0.01, 0.086) | 0.026 (0.005, 0.047) | 0.036 (0.007, 0.065) | 0.072 (0.014, 0.13) | 0.118 (0.114, 0.123) | ||
| Hormone_therapies | count | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | |
| time | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | ||
| n | 16 (11, 20) | 2 (1, 6) | 8 (4, 13) | 3 (1, 5) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | ||
| post_p | 0.7 (0.55, 0.89) | 0.6 (0.53, 0.73) | 0.7 (0.54, 0.88) | 0.64 (0.53, 0.77) | 0.52 (0.5, 0.56) | 0.54 (0.52, 0.57) | 0.54 (0.52, 0.6) | 0.54 (0.54, 0.58) | 0.55 (0.51, 0.67) | 0.55 (0.52, 0.75) | 0.59 (0.53, 0.73) | 0.6 (0.54, 0.75) | 0.52 (0.51, 0.55) | 0.53 (0.53, 0.53) | 0.59 (0.59, 0.59) | 0.52 (0.51, 0.57) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.077 (0.024, 0.103) | 0 (0, 0.127) | 0.048 (0, 0.099) | 0 (0, 0.155) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.049) | 0 (0, 0.204) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
| time | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | ||
| n | 2 (2, 3) | 1 (0, 2) | 4 (4, 5) | 2 (1, 4) | 2 (1, 2) | 3 (3, 3) | 1 (0, 2) | 2 (1, 2) | 0 (0, 0) | 2 (1, 2) | 0 (0, 1) | 2 (1, 2) | 0 (0, 1) | 2 (0, 3) | 0 (0, 1) | 2 (2, 2) | ||
| post_p | 0.6 (0.58, 0.61) | 0.58 (0.58, 0.58) | 0.64 (0.56, 0.72) | 0.59 (0.53, 0.64) | 0.61 (0.58, 0.65) | 0.7 (0.68, 0.72) | 0.58 (0.58, 0.58) | 0.51 (0.5, 0.52) | NA (NA, NA) | 0.55 (0.54, 0.56) | 0.57 (0.57, 0.57) | 0.54 (0.52, 0.55) | 0.63 (0.63, 0.63) | 0.51 (0.51, 0.51) | 0.62 (0.62, 0.62) | 0.56 (0.51, 0.61) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0) | 0 (0, 0) | 0.041 (0.008, 0.074) | 0 (0, 0) | 0 (0, 0) | 0.039 (0.008, 0.071) | 0 (0, 0) | 0.086 (0.017, 0.154) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.119 (0.108, 0.13) | ||
| DRD+ | Carboplatin | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||
| time | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | ||||||||||
| n | 5 (3, 7) | 6 (2, 8) | 3 (1, 5) | 3 (1, 5) | 4 (1, 5) | 4 (2, 6) | 4 (2, 5) | 2 (0, 4) | ||||||||||
| post_p | 0.61 (0.52, 0.78) | 0.8 (0.6, 0.95) | 0.7 (0.55, 0.79) | 0.68 (0.53, 0.75) | 0.56 (0.54, 0.75) | 0.66 (0.51, 0.82) | 0.6 (0.52, 0.82) | 0.69 (0.53, 0.89) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.114 (0.037, 0.144) | 0.023 (0, 0.108) | 0.068 (0, 0.108) | 0.107 (0.02, 0.231) | 0.018 (0, 0.13) | 0.074 (0.041, 0.124) | 0.098 (0, 0.204) | 0.07 (0, 0.149) | ||||||||||
| Hormone_therapies | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | |||||||||
| time | 16 (14, 22) | 16 (14, 22) | 16 (14, 22) | 16 (14, 22) | 16 (14, 22) | 16 (14, 22) | 16 (14, 22) | 16 (14, 22) | ||||||||||
| n | 5 (3, 10) | 6 (2, 9) | 2 (0, 4) | 5 (2, 7) | 3 (0, 4) | 2 (1, 6) | 2 (0, 4) | 4 (1, 7) | ||||||||||
| post_p | 0.61 (0.55, 0.75) | 0.86 (0.65, 0.96) | 0.66 (0.58, 0.82) | 0.74 (0.61, 0.92) | 0.6 (0.58, 0.74) | 0.6 (0.56, 0.72) | 0.66 (0.55, 0.76) | 0.65 (0.53, 0.88) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.07 (0.05, 0.089) | 0.046 (0.013, 0.09) | 0.041 (0, 0.148) | 0.078 (0, 0.137) | 0.049 (0, 0.059) | 0.063 (0.021, 0.084) | 0 (0, 0.138) | 0.039 (0, 0.106) | ||||||||||
| Niraparib | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | |||||||||
| time | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | ||||||||||
| n | 4 (3, 6) | 5 (2, 8) | 2 (1, 4) | 2 (1, 5) | 2 (2, 6) | 4 (2, 5) | 2 (0, 10) | 4 (2, 4) | ||||||||||
| post_p | 0.75 (0.55, 0.94) | 0.73 (0.6, 0.79) | 0.7 (0.56, 0.9) | 0.57 (0.52, 0.75) | 0.59 (0.53, 0.74) | 0.69 (0.54, 0.9) | 0.62 (0.51, 0.72) | 0.66 (0.55, 0.73) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.046 (0, 0.124) | 0.104 (0.033, 0.133) | 0.129 (0.034, 0.252) | 0.057 (0, 0.206) | 0.059 (0, 0.092) | 0.088 (0.033, 0.131) | 0.095 (0.013, 0.16) | 0.069 (0.027, 0.147) | ||||||||||
| TEfus+ | Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| time | 11 (10, 13) | 11 (10, 13) | 11 (10, 13) | 11 (10, 13) | 11 (10, 13) | 11 (10, 13) | 11 (10, 13) | 11 (10, 13) | ||||||||||
| n | 6 (4, 7) | 4 (3, 6) | 3 (3, 6) | 3 (1, 4) | 1 (0, 3) | 3 (1, 4) | 4 (1, 7) | 3 (3, 4) | ||||||||||
| post_p | 0.76 (0.73, 0.76) | 0.62 (0.61, 0.81) | 0.7 (0.63, 0.76) | 0.52 (0.51, 0.71) | 0.59 (0.56, 0.63) | 0.71 (0.55, 0.76) | 0.79 (0.78, 0.81) | 0.58 (0.56, 0.67) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0.028) | 0.086 (0.017, 0.089) | 0.025 (0.005, 0.047) | 0.068 (0.014, 0.303) | 0 (0, 0) | 0 (0, 0.056) | 0.102 (0.068, 0.136) | 0.073 (0.015, 0.154) | ||||||||||
| Hormone_therapies | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | |||||||||
| time | 16 (12, 31) | 16 (12, 31) | 16 (12, 31) | 16 (12, 31) | 16 (12, 31) | 16 (12, 31) | 16 (12, 31) | 16 (12, 31) | ||||||||||
| n | 5 (4, 16) | 14 (5, 31) | 3 (1, 7) | 2 (1, 4) | 5 (4, 10) | 4 (2, 11) | 2 (0, 5) | 4 (1, 13) | ||||||||||
| post_p | 0.7 (0.56, 0.81) | 0.85 (0.67, 0.96) | 0.75 (0.51, 0.82) | 0.64 (0.57, 0.68) | 0.79 (0.53, 0.91) | 0.65 (0.54, 0.72) | 0.68 (0.56, 0.81) | 0.77 (0.6, 0.93) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.089 (0.058, 0.12) | 0.089 (0.067, 0.127) | 0.045 (0, 0.091) | 0.064 (0, 0.15) | 0.06 (0.023, 0.119) | 0.084 (0, 0.105) | 0.028 (0, 0.083) | 0.073 (0.024, 0.215) | ||||||||||
| Niraparib | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | |||||||||
| time | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | ||||||||||
| n | 3 (1, 5) | 5 (4, 8) | 4 (2, 14) | 4 (3, 7) | 2 (2, 4) | 3 (0, 7) | 3 (1, 4) | 4 (2, 5) | ||||||||||
| post_p | 0.54 (0.52, 0.7) | 0.74 (0.52, 0.88) | 0.61 (0.51, 0.74) | 0.66 (0.51, 0.86) | 0.63 (0.51, 0.7) | 0.62 (0.57, 0.85) | 0.64 (0.55, 0.87) | 0.77 (0.54, 0.84) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.067 (0, 0.183) | 0.083 (0.045, 0.16) | 0.08 (0, 0.139) | 0.106 (0.038, 0.172) | 0 (0, 0.16) | 0.092 (0, 0.193) | 0.027 (0, 0.176) | 0.072 (0, 0.095) | ||||||||||
| TP53- & AR- | Carboplatin | count | 22 | 22 | 22 | 22 | ||||||||||||
| time | 15 (12, 31) | 15 (12, 31) | 15 (12, 31) | 15 (12, 31) | ||||||||||||||
| n | 20 (10, 57) | 4 (2, 13) | 8 (3, 17) | 6 (3, 12) | ||||||||||||||
| post_p | 0.78 (0.72, 0.9) | 0.72 (0.51, 0.91) | 0.73 (0.57, 0.87) | 0.73 (0.56, 0.9) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.088 (0.049, 0.113) | 0.065 (0, 0.139) | 0.084 (0.054, 0.111) | 0.079 (0.033, 0.137) | ||||||||||||||
| Hormone_therapies | count | 56 | 56 | 56 | 56 | |||||||||||||
| time | 10 (7, 20) | 10 (7, 20) | 10 (7, 20) | 10 (7, 20) | ||||||||||||||
| n | 26 (20, 48) | 4 (2, 8) | 1 (0, 5) | 2 (0, 6) | ||||||||||||||
| post_p | 0.8 (0.73, 0.92) | 0.69 (0.53, 0.83) | 0.6 (0.52, 0.73) | 0.6 (0.52, 0.81) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.083 (0.059, 0.107) | 0.069 (0, 0.125) | 0 (0, 0.094) | 0 (0, 0.098) | ||||||||||||||
| Niraparib | count | 32 | 32 | 32 | 32 | |||||||||||||
| time | 15 (10, 26) | 15 (10, 26) | 15 (10, 26) | 15 (10, 26) | ||||||||||||||
| n | 20 (12, 40) | 4 (1, 6) | 6 (4, 11) | 6 (4, 10) | ||||||||||||||
| post_p | 0.79 (0.74, 0.9) | 0.64 (0.54, 0.79) | 0.77 (0.54, 0.92) | 0.73 (0.57, 0.85) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.07 (0.032, 0.097) | 0.032 (0, 0.113) | 0.055 (0, 0.11) | 0.07 (0.026, 0.119) | ||||||||||||||
| Taxel_therapies | count | 31 | 31 | 31 | 31 | |||||||||||||
| time | 13 (9, 24) | 13 (9, 24) | 13 (9, 24) | 13 (9, 24) | ||||||||||||||
| n | 24 (17, 45) | 5 (2, 16) | 3 (0, 5) | 3 (1, 8) | ||||||||||||||
| post_p | 0.8 (0.73, 0.94) | 0.72 (0.54, 0.88) | 0.66 (0.53, 0.81) | 0.61 (0.52, 0.76) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.072 (0.045, 0.1) | 0.081 (0, 0.142) | 0 (0, 0.104) | 0 (0, 0.099) | ||||||||||||||
| TP53+ | Carboplatin | count | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | ||||||||
| time | 12 (9, 27) | 12 (9, 27) | 12 (9, 27) | 12 (9, 27) | 12 (9, 27) | 12 (9, 27) | 12 (9, 27) | 12 (9, 27) | ||||||||||
| n | 10 (4, 38) | 6 (2, 17) | 3 (1, 6) | 2 (0, 6) | 4 (1, 11) | 3 (1, 5) | 4 (1, 5) | 2 (0, 5) | ||||||||||
| post_p | 0.82 (0.62, 0.94) | 0.79 (0.54, 0.9) | 0.72 (0.59, 0.91) | 0.64 (0.58, 0.85) | 0.74 (0.52, 0.83) | 0.6 (0.52, 0.78) | 0.71 (0.58, 0.85) | 0.72 (0.6, 0.88) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.089 (0.039, 0.114) | 0.064 (0, 0.107) | 0.033 (0, 0.075) | 0.059 (0, 0.148) | 0.073 (0, 0.112) | 0.069 (0, 0.158) | 0.058 (0, 0.147) | 0.063 (0, 0.091) | ||||||||||
| Hormone_therapies | count | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | |||||||||
| time | 10 (8, 20) | 10 (8, 20) | 10 (8, 20) | 10 (8, 20) | 10 (8, 20) | 10 (8, 20) | 10 (8, 20) | 10 (8, 20) | ||||||||||
| n | 16 (9, 28) | 9 (5, 17) | 2 (0, 4) | 1 (0, 3) | 3 (0, 6) | 3 (0, 7) | 1 (0, 3) | 1 (0, 5) | ||||||||||
| post_p | 0.82 (0.72, 0.95) | 0.79 (0.65, 0.92) | 0.58 (0.51, 0.79) | 0.64 (0.55, 0.74) | 0.63 (0.56, 0.86) | 0.68 (0.54, 0.9) | 0.6 (0.57, 0.7) | 0.55 (0.5, 0.81) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.088 (0.052, 0.131) | 0.084 (0.037, 0.141) | 0 (0, 0.144) | 0 (0, 0.154) | 0.067 (0, 0.122) | 0.076 (0, 0.123) | 0 (0, 0.156) | 0 (0, 0.138) | ||||||||||
| Niraparib | count | 29 | 29 | 29 | 29 | 29 | 29 | 29 | 29 | |||||||||
| time | 13 (8, 32) | 13 (8, 32) | 13 (8, 32) | 13 (8, 32) | 13 (8, 32) | 13 (8, 32) | 13 (8, 32) | 13 (8, 32) | ||||||||||
| n | 11 (5, 37) | 5 (3, 14) | 3 (1, 6) | 4 (1, 9) | 4 (1, 5) | 3 (0, 9) | 4 (0, 8) | 4 (2, 8) | ||||||||||
| post_p | 0.8 (0.58, 0.96) | 0.73 (0.56, 0.87) | 0.71 (0.56, 0.9) | 0.67 (0.51, 0.83) | 0.69 (0.53, 0.9) | 0.71 (0.59, 0.86) | 0.73 (0.54, 0.92) | 0.74 (0.55, 0.93) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.085 (0.03, 0.111) | 0.081 (0, 0.128) | 0.087 (0, 0.171) | 0.073 (0, 0.16) | 0.051 (0, 0.123) | 0.072 (0, 0.147) | 0.075 (0, 0.134) | 0.067 (0, 0.104) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| time | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | ||
| n | 3 (3, 3) | 0 (0, 0) | 2 (2, 2) | 1 (1, 1) | 5 (5, 5) | 8 (8, 8) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | 1 (1, 1) | 2 (2, 2) | ||
| post_p | 0.27 (0.27, 0.27) | NA (NA, NA) | 0.39 (0.39, 0.39) | 0.27 (0.27, 0.27) | 0.16 (0.16, 0.16) | 0.45 (0.45, 0.45) | 0.25 (0.25, 0.25) | NA (NA, NA) | 0.34 (0.34, 0.34) | NA (NA, NA) | 0.24 (0.24, 0.24) | NA (NA, NA) | NA (NA, NA) | 0.35 (0.35, 0.35) | 0.44 (0.44, 0.44) | 0.32 (0.32, 0.32) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.322 (0.322, 0.322) | NA (NA, NA) | 0.206 (0.206, 0.206) | 2.238 (2.238, 2.238) | 0.074 (0.074, 0.074) | 0.201 (0.201, 0.201) | 2.036 (2.036, 2.036) | NA (NA, NA) | 1.442 (1.442, 1.442) | NA (NA, NA) | 0.2 (0.2, 0.2) | NA (NA, NA) | NA (NA, NA) | 0.294 (0.294, 0.294) | 0.249 (0.249, 0.249) | 0.369 (0.369, 0.369) | ||
| Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | ||
| n | 13 (9, 15) | 1 (0, 4) | 8 (7, 12) | 3 (1, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (0, 3) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.46 (0.19, 0.48) | 0.39 (0.3, 0.47) | 0.44 (0.37, 0.48) | 0.46 (0.34, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.37 (0.37, 0.37) | 0.48 (0.48, 0.48) | 0.47 (0.47, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.055 (0.053, 0.215) | 0.058 (0.012, 0.104) | 0.214 (0.139, 0.286) | 0.137 (0.027, 0.265) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.118 (0.024, 0.212) | 0 (0, 0) | 0.492 (0.492, 0.492) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| Taxel_therapies | count | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | |
| time | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | 20 (5, 34) | ||
| n | 11 (3, 41) | 3 (1, 9) | 5 (3, 10) | 8 (4, 13) | 2 (0, 8) | 1 (0, 4) | 2 (0, 3) | 1 (0, 4) | 5 (1, 11) | 4 (1, 9) | 3 (1, 13) | 3 (2, 9) | 1 (0, 5) | 1 (0, 7) | 2 (0, 4) | 1 (0, 3) | ||
| post_p | 0.28 (0.09, 0.44) | 0.26 (0.16, 0.43) | 0.21 (0.08, 0.45) | 0.26 (0.04, 0.46) | 0.34 (0.23, 0.45) | 0.41 (0.18, 0.48) | 0.28 (0.21, 0.42) | 0.28 (0.08, 0.45) | 0.35 (0.21, 0.41) | 0.32 (0.15, 0.48) | 0.33 (0.08, 0.46) | 0.3 (0.16, 0.46) | 0.36 (0.23, 0.47) | 0.36 (0.26, 0.5) | 0.4 (0.29, 0.49) | 0.3 (0.21, 0.43) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.142 (0.113, 0.785) | 0.258 (0.127, 0.583) | 0.271 (0.161, 0.527) | 0.216 (0.163, 0.546) | 0.163 (0.12, 0.786) | 0.168 (0, 0.288) | 0.309 (0.194, 0.683) | 0.304 (0.173, 0.77) | 0.179 (0.117, 0.47) | 0.166 (0.102, 0.436) | 0.292 (0.153, 1.058) | 0.271 (0.106, 0.678) | 0.279 (0.133, 1.477) | 0.163 (0.103, 0.406) | 0.189 (0.089, 0.98) | 0.253 (0.106, 1.298) | ||
| DRD+ | Carboplatin | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||||||||
| time | 16 (8, 28) | 16 (8, 28) | 16 (8, 28) | 16 (8, 28) | 16 (8, 28) | 16 (8, 28) | 16 (8, 28) | 16 (8, 28) | ||||||||||
| n | 6 (3, 12) | 4 (2, 8) | 4 (2, 4) | 4 (3, 7) | 3 (2, 9) | 4 (2, 6) | 2 (1, 5) | 3 (1, 6) | ||||||||||
| post_p | 0.29 (0.17, 0.46) | 0.44 (0.36, 0.48) | 0.42 (0.2, 0.5) | 0.34 (0.23, 0.46) | 0.4 (0.18, 0.47) | 0.36 (0.14, 0.44) | 0.33 (0.28, 0.41) | 0.39 (0.24, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.17 (0.107, 0.299) | 0.149 (0.131, 0.238) | 0.208 (0.121, 0.441) | 0.202 (0.112, 0.326) | 0.167 (0.092, 0.444) | 0.219 (0.045, 0.378) | 0.584 (0.114, 0.839) | 0.191 (0.144, 2.067) | ||||||||||
| Hormone_therapies | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | |||||||||
| time | 30 (23, 34) | 30 (23, 34) | 30 (23, 34) | 30 (23, 34) | 30 (23, 34) | 30 (23, 34) | 30 (23, 34) | 30 (23, 34) | ||||||||||
| n | 2 (0, 5) | 4 (0, 10) | 6 (2, 14) | 3 (2, 6) | 4 (1, 6) | 5 (3, 8) | 3 (2, 10) | 3 (1, 6) | ||||||||||
| post_p | 0.36 (0.1, 0.41) | 0.37 (0.31, 0.46) | 0.42 (0.18, 0.47) | 0.42 (0.29, 0.48) | 0.42 (0.27, 0.45) | 0.41 (0.24, 0.48) | 0.36 (0.33, 0.43) | 0.35 (0.19, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.237 (0.157, 0.553) | 0.146 (0.132, 0.306) | 0.156 (0.105, 0.316) | 0.2 (0.144, 0.29) | 0.153 (0.096, 0.51) | 0.162 (0.115, 0.266) | 0.163 (0.138, 0.286) | 0.219 (0.136, 0.302) | ||||||||||
| Niraparib | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 21 (17, 28) | 21 (17, 28) | 21 (17, 28) | 21 (17, 28) | 21 (17, 28) | 21 (17, 28) | 21 (17, 28) | 21 (17, 28) | ||||||||||
| n | 2 (1, 11) | 6 (5, 16) | 3 (1, 5) | 4 (3, 6) | 3 (2, 5) | 4 (3, 15) | 3 (2, 7) | 1 (1, 4) | ||||||||||
| post_p | 0.32 (0.12, 0.35) | 0.32 (0.18, 0.44) | 0.33 (0.17, 0.42) | 0.38 (0.14, 0.46) | 0.29 (0.21, 0.35) | 0.43 (0.24, 0.44) | 0.48 (0.28, 0.49) | 0.37 (0.28, 0.42) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.294 (0.17, 0.973) | 0.122 (0.097, 0.198) | 0.238 (0.147, 0.458) | 0.249 (0.125, 0.365) | 0.211 (0.154, 0.278) | 0.139 (0.131, 0.273) | 0.196 (0.123, 0.642) | 0.335 (0.21, 0.895) | ||||||||||
| Taxel_therapies | count | 60 | 60 | 60 | 60 | 60 | 60 | 60 | 60 | |||||||||
| time | 29 (22, 34) | 29 (22, 34) | 29 (22, 34) | 29 (22, 34) | 29 (22, 34) | 29 (22, 34) | 29 (22, 34) | 29 (22, 34) | ||||||||||
| n | 5 (2, 13) | 5 (2, 11) | 2 (1, 6) | 2 (1, 5) | 4 (1, 7) | 4 (1, 8) | 2 (1, 5) | 2 (0, 5) | ||||||||||
| post_p | 0.34 (0.16, 0.45) | 0.35 (0.13, 0.47) | 0.34 (0.21, 0.43) | 0.32 (0.15, 0.43) | 0.36 (0.19, 0.48) | 0.36 (0.22, 0.48) | 0.35 (0.21, 0.46) | 0.34 (0.21, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.158 (0.113, 0.413) | 0.159 (0.104, 0.348) | 0.294 (0.163, 0.786) | 0.294 (0.168, 0.885) | 0.165 (0.106, 0.573) | 0.178 (0.112, 0.664) | 0.265 (0.15, 1.697) | 0.306 (0.169, 1.229) | ||||||||||
| TEfus+ | Carboplatin | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||
| time | 21 (15, 32) | 21 (15, 32) | 21 (15, 32) | 21 (15, 32) | 21 (15, 32) | 21 (15, 32) | 21 (15, 32) | 21 (15, 32) | ||||||||||
| n | 3 (1, 5) | 6 (3, 16) | 4 (3, 9) | 3 (1, 4) | 4 (3, 11) | 3 (2, 6) | 4 (3, 6) | 3 (1, 6) | ||||||||||
| post_p | 0.23 (0.19, 0.36) | 0.38 (0.25, 0.49) | 0.44 (0.21, 0.49) | 0.32 (0.21, 0.44) | 0.39 (0.33, 0.47) | 0.41 (0.29, 0.47) | 0.35 (0.2, 0.46) | 0.36 (0.3, 0.44) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.252 (0.162, 1.371) | 0.163 (0.119, 0.338) | 0.125 (0.082, 0.206) | 0.249 (0.183, 0.474) | 0.122 (0.098, 0.336) | 0.2 (0.149, 0.489) | 0.147 (0.127, 0.341) | 0.196 (0.132, 0.929) | ||||||||||
| Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 26 (14, 29) | 26 (14, 29) | 26 (14, 29) | 26 (14, 29) | 26 (14, 29) | 26 (14, 29) | 26 (14, 29) | 26 (14, 29) | ||||||||||
| n | 4 (2, 7) | 11 (5, 13) | 4 (1, 9) | 3 (1, 3) | 4 (3, 5) | 4 (3, 6) | 3 (1, 4) | 3 (1, 7) | ||||||||||
| post_p | 0.33 (0.29, 0.37) | 0.41 (0.28, 0.46) | 0.46 (0.45, 0.46) | 0.34 (0.23, 0.46) | 0.33 (0.29, 0.39) | 0.41 (0.38, 0.43) | 0.32 (0.27, 0.44) | 0.45 (0.29, 0.47) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.222 (0.181, 0.477) | 0.142 (0.136, 0.166) | 0.127 (0.112, 0.142) | 0.377 (0.171, 0.776) | 0.128 (0.104, 0.211) | 0.135 (0.124, 0.184) | 0.239 (0.15, 0.341) | 0.24 (0.119, 0.703) | ||||||||||
| Niraparib | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 26 (18, 32) | 26 (18, 32) | 26 (18, 32) | 26 (18, 32) | 26 (18, 32) | 26 (18, 32) | 26 (18, 32) | 26 (18, 32) | ||||||||||
| n | 3 (2, 4) | 6 (3, 22) | 4 (3, 10) | 2 (0, 12) | 4 (3, 10) | 6 (1, 11) | 3 (1, 5) | 3 (1, 13) | ||||||||||
| post_p | 0.38 (0.29, 0.43) | 0.28 (0.21, 0.38) | 0.39 (0.24, 0.44) | 0.36 (0.31, 0.41) | 0.35 (0.17, 0.38) | 0.4 (0.4, 0.42) | 0.4 (0.24, 0.49) | 0.33 (0.21, 0.45) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.19 (0.122, 0.457) | 0.228 (0.151, 0.42) | 0.13 (0.128, 0.213) | 0.377 (0.152, 0.845) | 0.137 (0.111, 0.35) | 0.152 (0.124, 0.195) | 0.135 (0.122, 0.569) | 0.251 (0.157, 0.355) | ||||||||||
| Taxel_therapies | count | 106 | 106 | 106 | 106 | 106 | 106 | 106 | 106 | |||||||||
| time | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | ||||||||||
| n | 5 (2, 13) | 8 (5, 14) | 4 (1, 9) | 2 (0, 4) | 5 (2, 10) | 4 (2, 6) | 2 (0, 6) | 2 (0, 4) | ||||||||||
| post_p | 0.35 (0.14, 0.48) | 0.18 (0.03, 0.42) | 0.37 (0.2, 0.48) | 0.36 (0.2, 0.45) | 0.36 (0.18, 0.48) | 0.3 (0.14, 0.45) | 0.37 (0.21, 0.48) | 0.34 (0.21, 0.45) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.165 (0.098, 0.35) | 0.233 (0.168, 0.477) | 0.167 (0.102, 0.42) | 0.304 (0.165, 1.175) | 0.157 (0.092, 0.369) | 0.233 (0.146, 0.686) | 0.217 (0.105, 0.789) | 0.293 (0.161, 1.123) | ||||||||||
| TP53- & AR- | Carboplatin | count | 109 | 109 | 109 | 109 | ||||||||||||
| time | 21 (13, 31) | 21 (13, 31) | 21 (13, 31) | 21 (13, 31) | ||||||||||||||
| n | 19 (7, 52) | 4 (1, 8) | 6 (3, 13) | 6 (3, 12) | ||||||||||||||
| post_p | 0.32 (0.11, 0.47) | 0.36 (0.16, 0.48) | 0.34 (0.15, 0.48) | 0.36 (0.16, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.131 (0.105, 0.18) | 0.186 (0.103, 0.541) | 0.147 (0.096, 0.349) | 0.149 (0.095, 0.361) | ||||||||||||||
| Hormone_therapies | count | 145 | 145 | 145 | 145 | |||||||||||||
| time | 13 (7, 28) | 13 (7, 28) | 13 (7, 28) | 13 (7, 28) | ||||||||||||||
| n | 23 (16, 47) | 4 (2, 10) | 2 (0, 7) | 2 (0, 8) | ||||||||||||||
| post_p | 0.3 (0.11, 0.45) | 0.35 (0.16, 0.48) | 0.36 (0.23, 0.49) | 0.37 (0.22, 0.48) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.13 (0.105, 0.178) | 0.173 (0.102, 0.41) | 0.194 (0.087, 0.678) | 0.196 (0.107, 0.586) | ||||||||||||||
| Niraparib | count | 131 | 131 | 131 | 131 | |||||||||||||
| time | 23 (13, 31) | 23 (13, 31) | 23 (13, 31) | 23 (13, 31) | ||||||||||||||
| n | 16 (7, 55) | 4 (2, 11) | 7 (3, 13) | 6 (2, 13) | ||||||||||||||
| post_p | 0.3 (0.1, 0.47) | 0.36 (0.17, 0.48) | 0.34 (0.14, 0.48) | 0.34 (0.15, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.134 (0.108, 0.205) | 0.169 (0.114, 0.554) | 0.142 (0.099, 0.349) | 0.156 (0.09, 0.409) | ||||||||||||||
| Taxel_therapies | count | 121 | 121 | 121 | 121 | |||||||||||||
| time | 21 (13, 31) | 21 (13, 31) | 21 (13, 31) | 21 (13, 31) | ||||||||||||||
| n | 20 (9, 55) | 6 (2, 12) | 4 (2, 11) | 4 (1, 9) | ||||||||||||||
| post_p | 0.3 (0.1, 0.46) | 0.35 (0.14, 0.48) | 0.37 (0.18, 0.48) | 0.37 (0.2, 0.48) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.13 (0.109, 0.219) | 0.163 (0.097, 0.402) | 0.156 (0.101, 0.363) | 0.19 (0.107, 0.519) | ||||||||||||||
| TP53+ | Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| time | 17 (15, 28) | 17 (15, 28) | 17 (15, 28) | 17 (15, 28) | 17 (15, 28) | 17 (15, 28) | 17 (15, 28) | 17 (15, 28) | ||||||||||
| n | 7 (6, 8) | 9 (6, 18) | 2 (1, 3) | 5 (3, 5) | 5 (1, 6) | 3 (1, 4) | 1 (1, 2) | 4 (2, 7) | ||||||||||
| post_p | 0.41 (0.37, 0.42) | 0.45 (0.31, 0.46) | 0.44 (0.37, 0.46) | 0.45 (0.32, 0.48) | 0.37 (0.33, 0.4) | 0.42 (0.37, 0.43) | 0.35 (0.29, 0.36) | 0.37 (0.32, 0.43) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.158 (0.147, 0.17) | 0.18 (0.147, 0.252) | 0.137 (0.089, 0.476) | 0.197 (0.101, 0.383) | 0.129 (0.121, 0.137) | 0.2 (0.159, 0.242) | 0.493 (0.296, 0.655) | 0.201 (0.197, 0.847) | ||||||||||
| Hormone_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 11 (9, 12) | 11 (9, 12) | 11 (9, 12) | 11 (9, 12) | 11 (9, 12) | 11 (9, 12) | 11 (9, 12) | 11 (9, 12) | ||||||||||
| n | 16 (15, 17) | 4 (3, 4) | 1 (0, 3) | 1 (0, 2) | 1 (0, 4) | 2 (2, 3) | 2 (1, 2) | 2 (0, 4) | ||||||||||
| post_p | 0.36 (0.16, 0.49) | 0.3 (0.12, 0.44) | 0.5 (0.5, 0.5) | 0.35 (0.31, 0.42) | 0.44 (0.42, 0.46) | 0.4 (0.25, 0.47) | 0.32 (0.22, 0.41) | 0.27 (0.23, 0.4) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.151 (0.102, 0.179) | 0.243 (0.143, 0.379) | 0.074 (0.015, 0.133) | 0.687 (0.282, 0.838) | 0.165 (0.148, 0.182) | 0.162 (0.112, 0.307) | 0.22 (0.049, 1.008) | 0.819 (0.247, 4.35) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | ||||||||||
| n | 6 (6, 6) | 7 (7, 7) | 6 (6, 6) | 4 (4, 4) | 3 (3, 3) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | ||||||||||
| post_p | 0.24 (0.24, 0.24) | 0.44 (0.44, 0.44) | 0.44 (0.44, 0.44) | 0.36 (0.36, 0.36) | 0.49 (0.49, 0.49) | 0.25 (0.25, 0.25) | 0.26 (0.26, 0.26) | 0.41 (0.41, 0.41) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.176 (0.176, 0.176) | 0.188 (0.188, 0.188) | 0.11 (0.11, 0.11) | 0.202 (0.202, 0.202) | 0.136 (0.136, 0.136) | 0.291 (0.291, 0.291) | 0.348 (0.348, 0.348) | 0.19 (0.19, 0.19) | ||||||||||
| Taxel_therapies | count | 366 | 366 | 366 | 366 | 366 | 366 | 366 | 366 | |||||||||
| time | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | ||||||||||
| n | 7 (4, 14) | 8 (5, 15) | 2 (0, 5) | 2 (0, 5) | 4 (2, 8) | 4 (2, 8) | 2 (0, 5) | 2 (0, 5) | ||||||||||
| post_p | 0.2 (0.07, 0.41) | 0.17 (0.04, 0.42) | 0.34 (0.2, 0.47) | 0.35 (0.2, 0.47) | 0.29 (0.11, 0.45) | 0.28 (0.13, 0.47) | 0.35 (0.19, 0.47) | 0.34 (0.21, 0.47) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.246 (0.16, 0.45) | 0.249 (0.162, 0.49) | 0.292 (0.139, 0.991) | 0.272 (0.137, 1.198) | 0.268 (0.152, 0.723) | 0.255 (0.141, 0.729) | 0.28 (0.142, 1.205) | 0.287 (0.143, 1.245) |