Simulation scenario 8

Setting description

Taxel_therapies less effective in the TP53+ biomarker signature

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.164, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6, median = 4.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.68, hr = 1.5	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.164, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6, median = 4.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.68, hr = 1.5	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.164, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6, median = 4.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.68, hr = 1.5	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 20 0 2 2 TP53- & AR- 56 31 22 32 TP53+ 34 0 12 29 DRD+ 6 0 8 6 TEfus+ 9 0 3 11

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.040 0.000 0.004 0.004 TP53- & AR- 0.112 0.062 0.044 0.064 TP53+ 0.068 0.000 0.024 0.058 DRD+ 0.012 0.000 0.016 0.012 TEfus+ 0.018 0.000 0.006 0.022

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 3 23 1 0 TP53- & AR- 145 121 109 131 TP53+ 4 366 3 1 DRD+ 9 60 10 5 TEfus+ 3 106 8 5

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.006 0.046 0.002 0.000 TP53- & AR- 0.290 0.242 0.218 0.262 TP53+ 0.008 0.732 0.006 0.002 DRD+ 0.018 0.120 0.020 0.010 TEfus+ 0.006 0.212 0.016 0.010

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 23 12 17 12 TP53+ 23 0 38 28 DRD+ 0 0 0 0 TEfus+ 0 0 1 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.046 0.024 0.034 0.024 TP53+ 0.046 0.000 0.076 0.056 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.002 0.000

Errors & power

The overall error was 0.44.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.226             0.062             0.082             0.140 

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	2	0	20	2	0
	futility	1	0	3	0	23
	max_n	0	0	0	0	0
	n	207 (151, 270)	434 (401, 467)	197 (131, 270)	202 (145, 269)	135 (94, 199)
	n_unique	189 (136, 249)	392 (362, 424)	180 (119, 251)	185 (129, 247)	123 (85, 184)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	8 (7, 22)	NA (NA, NA)	5 (3, 6)	6 (6, 6)	20 (5, 34)
	post_p	0.84 (0.37, 0.99)	NA (NA, NA)	0.82 (0.33, 0.99)	0.83 (0.36, 0.99)	0.2 (0.01, 0.74)
	rate	0.112 (0.102, 0.124)	0.123 (0.115, 0.132)	0.112 (0.102, 0.126)	0.112 (0.101, 0.125)	0.134 (0.119, 0.164)
DRD+	graduation	8	0	6	6	0
	futility	10	0	9	5	60
	max_n	0	0	0	0	0
	n	68 (47, 90)	118 (102, 134)	47 (26, 68)	65 (44, 86)	38 (23, 57)
	n_unique	62 (41, 82)	105 (91, 120)	42 (23, 62)	58 (40, 78)	34 (20, 52)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (34, 36)
	time_stop	13 (9, 26)	NA (NA, NA)	24 (15, 33)	16 (9, 22)	29 (22, 34)
	post_p	0.72 (0.26, 0.96)	NA (NA, NA)	0.64 (0.19, 0.94)	0.69 (0.23, 0.96)	0.31 (0.04, 0.79)
	rate	0.111 (0.095, 0.134)	0.123 (0.107, 0.14)	0.113 (0.093, 0.144)	0.113 (0.095, 0.139)	0.136 (0.107, 0.19)
TEfus+	graduation	3	0	9	11	0
	futility	8	0	3	5	106
	max_n	1	0	0	0	0
	n	80 (55, 107)	159 (138, 177)	73 (40, 100)	78 (49, 108)	52 (29, 74)
	n_unique	71 (49, 98)	143 (125, 160)	66 (35, 91)	70 (44, 98)	47 (27, 67)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (20, 36)
	time_stop	17 (11, 31)	NA (NA, NA)	18 (11, 30)	16 (10, 26)	21 (12, 32)
	post_p	0.74 (0.28, 0.97)	NA (NA, NA)	0.75 (0.27, 0.98)	0.75 (0.27, 0.98)	0.21 (0.01, 0.71)
	rate	0.113 (0.096, 0.134)	0.125 (0.11, 0.141)	0.113 (0.093, 0.134)	0.113 (0.096, 0.135)	0.145 (0.116, 0.187)
TP53- & AR-	graduation	22	0	56	32	31
	futility	109	0	145	131	121
	max_n	17	0	23	12	12
	n	73 (29, 128)	178 (153, 204)	64 (25, 133)	66 (26, 125)	65 (26, 124)
	n_unique	66 (26, 120)	163 (138, 186)	59 (24, 128)	60 (24, 117)	60 (24, 117)
	time_trial	36 (17, 36)	36 (36, 36)	36 (9, 36)	36 (16, 36)	36 (16, 36)
	time_stop	20 (13, 31)	NA (NA, NA)	12 (7, 27)	21 (11, 31)	20 (12, 31)
	post_p	0.48 (0.1, 0.88)	NA (NA, NA)	0.49 (0.07, 0.89)	0.5 (0.1, 0.9)	0.44 (0.08, 0.9)
	rate	0.114 (0.098, 0.14)	0.113 (0.1, 0.127)	0.114 (0.097, 0.143)	0.114 (0.094, 0.145)	0.115 (0.098, 0.146)
TP53+	graduation	12	0	34	29	0
	futility	3	0	4	1	366
	max_n	38	0	23	28	0
	n	102 (69, 143)	192 (173, 216)	103 (39, 139)	102 (68, 140)	37 (25, 55)
	n_unique	92 (61, 131)	173 (154, 196)	94 (35, 128)	93 (61, 130)	33 (23, 51)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	25 (12, 36)
	time_stop	12 (9, 30)	NA (NA, NA)	10 (8, 19)	13 (8, 32)	20 (11, 32)
	post_p	0.94 (0.54, 1)	NA (NA, NA)	0.93 (0.55, 1)	0.93 (0.59, 1)	0.01 (0, 0.06)
	rate	0.112 (0.098, 0.133)	0.139 (0.124, 0.153)	0.112 (0.097, 0.131)	0.113 (0.096, 0.13)	0.226 (0.186, 0.293)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	134	0	223	165	164
	futility	0	0	0	0	0
	max_n	17	0	23	12	12
	n	36 (9, 91)	114 (93, 133)	35 (17, 100)	34 (9, 87)	34 (10, 92)
	n_unique	34 (8, 85)	104 (85, 124)	33 (16, 95)	32 (8, 82)	32 (8, 86)
	post_p	0.42 (0.08, 0.89)	NA (NA, NA)	0.45 (0.1, 0.9)	0.43 (0.1, 0.89)	0.39 (0.1, 0.89)
	rate	0.117 (0.093, 0.19)	0.113 (0.097, 0.13)	0.117 (0.094, 0.157)	0.117 (0.093, 0.185)	0.121 (0.094, 0.187)
—+	graduation	139	0	231	178	219
	futility	0	0	0	0	0
	max_n	18	0	23	12	12
	n	7 (2, 20)	22 (15, 29)	7 (2, 20)	7 (2, 19)	8 (3, 21)
	n_unique	7 (2, 18)	20 (14, 27)	6 (2, 18)	6 (2, 17)	8 (2, 19)
	post_p	0.46 (0.18, 0.85)	NA (NA, NA)	0.46 (0.18, 0.83)	0.48 (0.18, 0.86)	0.46 (0.16, 0.83)
	rate	0.127 (0.075, 0.325)	0.115 (0.085, 0.157)	0.128 (0.075, 0.31)	0.123 (0.073, 0.328)	0.127 (0.081, 0.319)
–+-	graduation	17	0	60	32	375
	futility	0	0	0	0	0
	max_n	38	0	23	28	0
	n	32 (8, 59)	64 (52, 78)	37 (10, 63)	33 (8, 59)	7 (4, 15)
	n_unique	29 (7, 55)	57 (46, 72)	34 (10, 59)	30 (7, 54)	7 (3, 14)
	post_p	0.76 (0.22, 0.98)	NA (NA, NA)	0.78 (0.26, 0.98)	0.74 (0.22, 0.98)	0.16 (0.06, 0.36)
	rate	0.116 (0.089, 0.21)	0.14 (0.116, 0.164)	0.116 (0.091, 0.169)	0.117 (0.09, 0.187)	0.252 (0.165, 0.451)
–++	graduation	28	0	69	44	399
	futility	0	0	0	0	0
	max_n	39	0	23	28	0
	n	21 (5, 38)	44 (34, 54)	23 (5, 41)	20 (5, 37)	8 (5, 15)
	n_unique	18 (4, 35)	40 (30, 50)	21 (4, 38)	18 (5, 35)	8 (4, 14)
	post_p	0.66 (0.21, 0.96)	NA (NA, NA)	0.72 (0.24, 0.97)	0.71 (0.24, 0.96)	0.14 (0.04, 0.37)
	rate	0.121 (0.085, 0.243)	0.139 (0.113, 0.173)	0.115 (0.087, 0.203)	0.117 (0.085, 0.2)	0.246 (0.169, 0.476)
-+–	graduation	149	0	227	167	198
	futility	0	0	0	0	0
	max_n	17	0	23	12	12
	n	11 (3, 23)	21 (15, 28)	5 (0, 16)	9 (3, 19)	7 (2, 19)
	n_unique	10 (3, 21)	19 (13, 25)	4 (0, 14)	8 (2, 18)	6 (2, 17)
	post_p	0.47 (0.17, 0.86)	NA (NA, NA)	0.45 (0.18, 0.81)	0.46 (0.18, 0.8)	0.45 (0.17, 0.84)
	rate	0.119 (0.081, 0.251)	0.115 (0.08, 0.157)	0.126 (0.075, 0.384)	0.125 (0.08, 0.278)	0.122 (0.077, 0.336)
-+-+	graduation	153	0	235	179	245
	futility	0	0	0	0	0
	max_n	18	0	23	12	12
	n	10 (3, 23)	21 (15, 28)	5 (0, 18)	9 (3, 21)	6 (2, 18)
	n_unique	9 (3, 20)	19 (13, 26)	4 (0, 16)	8 (3, 19)	6 (1, 16)
	post_p	0.45 (0.17, 0.83)	NA (NA, NA)	0.44 (0.19, 0.83)	0.47 (0.17, 0.87)	0.42 (0.18, 0.84)
	rate	0.126 (0.078, 0.234)	0.112 (0.082, 0.161)	0.126 (0.071, 0.319)	0.12 (0.079, 0.26)	0.132 (0.079, 0.32)
-++-	graduation	32	0	75	42	382
	futility	0	0	0	0	0
	max_n	38	0	23	28	0
	n	7 (2, 13)	13 (8, 18)	5 (1, 12)	7 (2, 15)	2 (0, 6)
	n_unique	6 (2, 12)	11 (7, 16)	4 (1, 11)	6 (2, 14)	2 (0, 5)
	post_p	0.59 (0.26, 0.88)	NA (NA, NA)	0.55 (0.24, 0.9)	0.6 (0.25, 0.92)	0.32 (0.17, 0.51)
	rate	0.128 (0.066, 0.326)	0.141 (0.09, 0.23)	0.125 (0.065, 0.37)	0.123 (0.071, 0.313)	0.29 (0.141, 0.876)
-+++	graduation	41	0	82	54	404
	futility	0	0	0	0	0
	max_n	39	0	23	28	0
	n	7 (2, 14)	13 (8, 18)	5 (1, 11)	7 (2, 15)	2 (1, 5)
	n_unique	6 (2, 13)	11 (7, 16)	4 (1, 10)	6 (2, 14)	2 (0, 5)
	post_p	0.56 (0.25, 0.91)	NA (NA, NA)	0.54 (0.24, 0.87)	0.54 (0.25, 0.88)	0.33 (0.18, 0.5)
	rate	0.124 (0.071, 0.36)	0.136 (0.09, 0.225)	0.134 (0.064, 0.375)	0.131 (0.076, 0.3)	0.282 (0.139, 1.075)
+—	graduation	3	0	23	2	23
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (3, 18)	20 (15, 28)	8 (2, 19)	8 (3, 18)	11 (4, 21)
	n_unique	7 (2, 16)	18 (13, 26)	8 (2, 18)	7 (2, 16)	10 (3, 19)
	post_p	0.46 (0.17, 0.83)	NA (NA, NA)	0.48 (0.17, 0.86)	0.45 (0.19, 0.83)	0.48 (0.18, 0.86)
	rate	0.126 (0.077, 0.348)	0.115 (0.085, 0.162)	0.125 (0.079, 0.315)	0.129 (0.077, 0.319)	0.121 (0.082, 0.259)
+–+	graduation	14	0	35	18	115
	futility	0	0	0	0	0
	max_n	1	0	0	0	0
	n	6 (2, 14)	16 (10, 23)	6 (2, 14)	6 (2, 15)	8 (3, 17)
	n_unique	5 (2, 13)	14 (9, 21)	5 (1, 13)	6 (2, 13)	8 (2, 16)
	post_p	0.46 (0.21, 0.81)	NA (NA, NA)	0.42 (0.18, 0.82)	0.46 (0.19, 0.84)	0.46 (0.18, 0.87)
	rate	0.126 (0.074, 0.366)	0.113 (0.08, 0.168)	0.135 (0.074, 0.408)	0.124 (0.071, 0.362)	0.123 (0.074, 0.306)
+-+-	graduation	17	0	60	32	375
	futility	0	0	0	0	0
	max_n	38	0	23	28	0
	n	8 (3, 17)	17 (12, 23)	7 (2, 17)	8 (2, 17)	4 (2, 9)
	n_unique	7 (2, 16)	15 (10, 21)	6 (1, 15)	7 (2, 16)	4 (2, 9)
	post_p	0.59 (0.25, 0.92)	NA (NA, NA)	0.56 (0.27, 0.89)	0.61 (0.26, 0.92)	0.26 (0.11, 0.48)
	rate	0.125 (0.077, 0.33)	0.139 (0.099, 0.211)	0.127 (0.08, 0.293)	0.118 (0.069, 0.281)	0.258 (0.153, 0.68)
+-++	graduation	28	0	69	44	399
	futility	0	0	0	0	0
	max_n	39	0	23	28	0
	n	8 (2, 17)	17 (11, 23)	7 (2, 16)	8 (2, 17)	4 (2, 8)
	n_unique	7 (2, 15)	15 (10, 21)	6 (1, 15)	7 (2, 15)	4 (1, 8)
	post_p	0.57 (0.24, 0.93)	NA (NA, NA)	0.6 (0.24, 0.92)	0.57 (0.24, 0.92)	0.27 (0.12, 0.49)
	rate	0.122 (0.071, 0.376)	0.138 (0.099, 0.208)	0.124 (0.074, 0.353)	0.122 (0.073, 0.308)	0.248 (0.152, 0.716)
++–	graduation	21	0	38	13	77
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 13)	12 (7, 17)	4 (1, 10)	6 (2, 12)	5 (2, 10)
	n_unique	6 (2, 12)	10 (6, 15)	4 (1, 9)	5 (2, 11)	4 (1, 9)
	post_p	0.49 (0.22, 0.83)	NA (NA, NA)	0.45 (0.2, 0.8)	0.47 (0.2, 0.84)	0.46 (0.21, 0.82)
	rate	0.12 (0.073, 0.326)	0.115 (0.074, 0.18)	0.134 (0.068, 0.461)	0.122 (0.073, 0.371)	0.127 (0.066, 0.419)
++-+	graduation	30	0	48	28	153
	futility	0	0	0	0	0
	max_n	1	0	0	0	0
	n	6 (2, 13)	12 (8, 18)	5 (1, 10)	6 (2, 13)	5 (1, 11)
	n_unique	5 (2, 12)	11 (6, 16)	4 (1, 9)	5 (2, 12)	4 (1, 10)
	post_p	0.46 (0.19, 0.82)	NA (NA, NA)	0.45 (0.21, 0.8)	0.45 (0.18, 0.82)	0.44 (0.22, 0.83)
	rate	0.128 (0.068, 0.324)	0.113 (0.076, 0.179)	0.132 (0.064, 0.432)	0.132 (0.072, 0.361)	0.126 (0.065, 0.435)
+++-	graduation	32	0	75	42	382
	futility	0	0	0	0	0
	max_n	38	0	23	28	0
	n	7 (2, 15)	12 (8, 18)	4 (1, 11)	7 (2, 14)	2 (1, 6)
	n_unique	7 (2, 14)	11 (7, 16)	4 (1, 10)	7 (2, 14)	2 (0, 5)
	post_p	0.61 (0.26, 0.92)	NA (NA, NA)	0.58 (0.26, 0.89)	0.62 (0.26, 0.91)	0.34 (0.19, 0.5)
	rate	0.128 (0.072, 0.351)	0.145 (0.096, 0.233)	0.126 (0.068, 0.354)	0.122 (0.073, 0.344)	0.263 (0.139, 1.024)
++++	graduation	41	0	82	54	404
	futility	0	0	0	0	0
	max_n	39	0	23	28	0
	n	8 (2, 14)	13 (8, 18)	5 (1, 11)	6 (2, 13)	2 (0, 5)
	n_unique	7 (2, 13)	11 (7, 16)	4 (1, 10)	5 (2, 12)	2 (0, 5)
	post_p	0.57 (0.27, 0.91)	NA (NA, NA)	0.54 (0.27, 0.88)	0.56 (0.25, 0.89)	0.32 (0.2, 0.51)
	rate	0.123 (0.073, 0.354)	0.141 (0.092, 0.212)	0.125 (0.068, 0.418)	0.127 (0.074, 0.342)	0.274 (0.143, 1.106)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Carboplatin	Niraparib	Taxel_therapies
all	count	20	2	2
	time_stop	5 (3, 6)	16 (9, 24)	6 (6, 6)
	n_trt	32 (26, 46)	106 (54, 159)	26 (25, 26)
	n_control	54 (42, 69)	190 (96, 283)	68 (66, 70)
	post_p	0.92 (0.87, 0.97)	0.99 (0.98, 0.99)	0.94 (0.92, 0.96)
	order	1 (1, 1)	1.5 (1.1, 1.9)	1 (1, 1)
TP53- & AR-	count	56	22	32	31
	time_stop	10 (7, 20)	15 (12, 31)	15 (10, 26)	13 (9, 24)
	n_trt	32 (26, 68)	40 (27, 100)	38 (26, 71)	32 (26, 63)
	n_control	48 (30, 87)	69 (49, 153)	64 (43, 121)	60 (43, 108)
	post_p	0.91 (0.86, 0.96)	0.94 (0.86, 0.98)	0.95 (0.88, 0.99)	0.92 (0.87, 0.98)
	order	1 (1, 2)	1 (1, 2)	1 (1, 2)	1 (1, 2)
TP53+	count	34	12	29
	time_stop	10 (8, 20)	12 (9, 27)	13 (8, 32)
	n_trt	32 (26, 67)	32 (25, 78)	36 (26, 96)
	n_control	46 (33, 93)	54 (37, 128)	67 (35, 157)
	post_p	0.97 (0.88, 1)	0.99 (0.96, 1)	0.99 (0.94, 1)
	order	1 (1, 2)	1 (1, 1.9)	1 (1, 2.2)
DRD+	count	6	8	6
	time_stop	16 (14, 22)	11 (10, 14)	12 (8, 16)
	n_trt	26 (25, 37)	26 (26, 33)	28 (25, 36)
	n_control	50 (35, 64)	30 (21, 41)	32 (22, 52)
	post_p	0.99 (0.97, 1)	0.95 (0.87, 0.98)	0.97 (0.94, 0.98)
	order	1 (1, 3)	1 (1, 2)	2 (1, 3)
TEfus+	count	9	3	11
	time_stop	16 (12, 31)	11 (10, 13)	12 (10, 17)
	n_trt	35 (26, 72)	27 (25, 33)	29 (25, 48)
	n_control	56 (37, 152)	42 (39, 49)	46 (29, 63)
	post_p	0.99 (0.94, 1)	0.98 (0.94, 1)	0.95 (0.92, 0.99)
	order	2 (1, 3)	2 (1.2, 2.8)	1 (1, 1)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	3	23	1
	time_stop	4 (4, 5)	20 (5, 34)	8 (8, 8)
	n_trt	27 (26, 33)	65 (27, 119)	29 (29, 29)
	n_control	48 (47, 54)	218 (56, 426)	83 (83, 83)
	post_p	0.26 (0.13, 0.28)	0 (0, 0.05)	0.02 (0.02, 0.02)
	order	1 (1, 1)	2 (1, 5.8)	1 (1, 1)
TP53- & AR-	count	145	121	109	131
	time_stop	13 (7, 28)	21 (13, 31)	21 (13, 31)	23 (13, 31)
	n_trt	30 (25, 65)	36 (25, 78)	35 (25, 73)	33 (25, 75)
	n_control	60 (31, 133)	101 (57, 161)	90 (59, 143)	101 (58, 156)
	post_p	0.18 (0.04, 0.28)	0.16 (0.04, 0.26)	0.14 (0.04, 0.27)	0.13 (0.03, 0.27)
	order	1 (1, 2)	2 (1, 3)	2 (1, 3.2)	2 (1, 3)
TP53+	count	4	366	3	1
	time_stop	11 (9, 12)	20 (11, 32)	17 (15, 28)	20 (20, 20)
	n_trt	30 (28, 31)	33 (25, 47)	34 (30, 44)	32 (32, 32)
	n_control	50 (36, 63)	100 (48, 169)	80 (76, 147)	101 (101, 101)
	post_p	0.19 (0.04, 0.27)	0.01 (0, 0.08)	0.12 (0.08, 0.16)	0.08 (0.08, 0.08)
	order	1.5 (1, 2)	1 (1, 3)	2 (1.2, 3.6)	4 (4, 4)
DRD+	count	9	60	10	5
	time_stop	30 (23, 34)	29 (22, 34)	16 (8, 28)	21 (17, 28)
	n_trt	34 (28, 44)	29 (25, 39)	30 (25, 46)	31 (27, 56)
	n_control	100 (69, 115)	85 (59, 115)	46 (17, 74)	64 (46, 99)
	post_p	0.05 (0.02, 0.16)	0.06 (0.01, 0.2)	0.07 (0.03, 0.14)	0.01 (0.01, 0.09)
	order	3 (2, 4)	3 (2, 4.1)	1.5 (1, 3.1)	4 (2.4, 4)
TEfus+	count	3	106	8	5
	time_stop	26 (14, 29)	21 (12, 32)	21 (15, 32)	26 (18, 32)
	n_trt	34 (28, 44)	33 (26, 52)	34 (26, 50)	42 (27, 67)
	n_control	112 (54, 117)	80 (44, 144)	100 (61, 141)	107 (66, 152)
	post_p	0.1 (0.03, 0.22)	0.03 (0, 0.16)	0.06 (0.02, 0.19)	0.08 (0.02, 0.14)
	order	2 (1.2, 4.4)	2 (1, 4)	3 (1.7, 4)	2 (1.4, 4.2)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)
		n	26 (9, 44)	4 (2, 5)	16 (7, 24)	6 (3, 9)	10 (5, 15)	7 (1, 13)	2 (2, 3)	6 (5, 7)	2 (2, 3)	3 (1, 5)	8 (6, 10)	2 (1, 3)	3 (3, 3)	6 (3, 10)	3 (1, 5)	2 (1, 2)
		post_p	0.66 (0.56, 0.76)	0.54 (0.52, 0.56)	0.78 (0.64, 0.92)	0.69 (0.57, 0.82)	0.63 (0.58, 0.68)	0.6 (0.6, 0.6)	0.62 (0.58, 0.65)	0.66 (0.6, 0.72)	0.56 (0.56, 0.57)	0.61 (0.61, 0.61)	0.68 (0.59, 0.77)	0.59 (0.58, 0.6)	0.61 (0.53, 0.69)	0.72 (0.64, 0.79)	0.6 (0.56, 0.64)	0.64 (0.64, 0.65)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.093 (0.09, 0.096)	0.048 (0.01, 0.087)	0.089 (0.088, 0.09)	0.043 (0.009, 0.078)	0.128 (0.101, 0.156)	0.109 (0.109, 0.109)	0.049 (0.01, 0.088)	0.064 (0.051, 0.077)	0.052 (0.01, 0.094)	0.076 (0.076, 0.076)	0.068 (0.014, 0.122)	0.048 (0.01, 0.086)	0.026 (0.005, 0.047)	0.036 (0.007, 0.065)	0.072 (0.014, 0.13)	0.118 (0.114, 0.123)
	Hormone_therapies	count	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20
		time	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)
		n	16 (11, 20)	2 (1, 6)	8 (4, 13)	3 (1, 5)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)
		post_p	0.7 (0.55, 0.89)	0.6 (0.53, 0.73)	0.7 (0.54, 0.88)	0.64 (0.53, 0.77)	0.52 (0.5, 0.56)	0.54 (0.52, 0.57)	0.54 (0.52, 0.6)	0.54 (0.54, 0.58)	0.55 (0.51, 0.67)	0.55 (0.52, 0.75)	0.59 (0.53, 0.73)	0.6 (0.54, 0.75)	0.52 (0.51, 0.55)	0.53 (0.53, 0.53)	0.59 (0.59, 0.59)	0.52 (0.51, 0.57)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.077 (0.024, 0.103)	0 (0, 0.127)	0.048 (0, 0.099)	0 (0, 0.155)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.049)	0 (0, 0.204)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Niraparib	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	2 (2, 3)	1 (0, 2)	4 (4, 5)	2 (1, 4)	2 (1, 2)	3 (3, 3)	1 (0, 2)	2 (1, 2)	0 (0, 0)	2 (1, 2)	0 (0, 1)	2 (1, 2)	0 (0, 1)	2 (0, 3)	0 (0, 1)	2 (2, 2)
		post_p	0.6 (0.58, 0.61)	0.58 (0.58, 0.58)	0.64 (0.56, 0.72)	0.59 (0.53, 0.64)	0.61 (0.58, 0.65)	0.7 (0.68, 0.72)	0.58 (0.58, 0.58)	0.51 (0.5, 0.52)	NA (NA, NA)	0.55 (0.54, 0.56)	0.57 (0.57, 0.57)	0.54 (0.52, 0.55)	0.63 (0.63, 0.63)	0.51 (0.51, 0.51)	0.62 (0.62, 0.62)	0.56 (0.51, 0.61)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0.041 (0.008, 0.074)	0 (0, 0)	0 (0, 0)	0.039 (0.008, 0.071)	0 (0, 0)	0.086 (0.017, 0.154)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.119 (0.108, 0.13)
DRD+	Carboplatin	count					8	8	8	8					8	8	8	8
		time					11 (10, 14)	11 (10, 14)	11 (10, 14)	11 (10, 14)					11 (10, 14)	11 (10, 14)	11 (10, 14)	11 (10, 14)
		n					5 (3, 7)	6 (2, 8)	3 (1, 5)	3 (1, 5)					4 (1, 5)	4 (2, 6)	4 (2, 5)	2 (0, 4)
		post_p					0.61 (0.52, 0.78)	0.8 (0.6, 0.95)	0.7 (0.55, 0.79)	0.68 (0.53, 0.75)					0.56 (0.54, 0.75)	0.66 (0.51, 0.82)	0.6 (0.52, 0.82)	0.69 (0.53, 0.89)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.114 (0.037, 0.144)	0.023 (0, 0.108)	0.068 (0, 0.108)	0.107 (0.02, 0.231)					0.018 (0, 0.13)	0.074 (0.041, 0.124)	0.098 (0, 0.204)	0.07 (0, 0.149)
	Hormone_therapies	count					6	6	6	6					6	6	6	6
		time					16 (14, 22)	16 (14, 22)	16 (14, 22)	16 (14, 22)					16 (14, 22)	16 (14, 22)	16 (14, 22)	16 (14, 22)
		n					5 (3, 10)	6 (2, 9)	2 (0, 4)	5 (2, 7)					3 (0, 4)	2 (1, 6)	2 (0, 4)	4 (1, 7)
		post_p					0.61 (0.55, 0.75)	0.86 (0.65, 0.96)	0.66 (0.58, 0.82)	0.74 (0.61, 0.92)					0.6 (0.58, 0.74)	0.6 (0.56, 0.72)	0.66 (0.55, 0.76)	0.65 (0.53, 0.88)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.07 (0.05, 0.089)	0.046 (0.013, 0.09)	0.041 (0, 0.148)	0.078 (0, 0.137)					0.049 (0, 0.059)	0.063 (0.021, 0.084)	0 (0, 0.138)	0.039 (0, 0.106)
	Niraparib	count					6	6	6	6					6	6	6	6
		time					12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)					12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)
		n					4 (3, 6)	5 (2, 8)	2 (1, 4)	2 (1, 5)					2 (2, 6)	4 (2, 5)	2 (0, 10)	4 (2, 4)
		post_p					0.75 (0.55, 0.94)	0.73 (0.6, 0.79)	0.7 (0.56, 0.9)	0.57 (0.52, 0.75)					0.59 (0.53, 0.74)	0.69 (0.54, 0.9)	0.62 (0.51, 0.72)	0.66 (0.55, 0.73)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.046 (0, 0.124)	0.104 (0.033, 0.133)	0.129 (0.034, 0.252)	0.057 (0, 0.206)					0.059 (0, 0.092)	0.088 (0.033, 0.131)	0.095 (0.013, 0.16)	0.069 (0.027, 0.147)
TEfus+	Carboplatin	count		3		3		3		3		3		3		3		3
		time		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)
		n		6 (4, 7)		4 (3, 6)		3 (3, 6)		3 (1, 4)		1 (0, 3)		3 (1, 4)		4 (1, 7)		3 (3, 4)
		post_p		0.76 (0.73, 0.76)		0.62 (0.61, 0.81)		0.7 (0.63, 0.76)		0.52 (0.51, 0.71)		0.59 (0.56, 0.63)		0.71 (0.55, 0.76)		0.79 (0.78, 0.81)		0.58 (0.56, 0.67)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0.028)		0.086 (0.017, 0.089)		0.025 (0.005, 0.047)		0.068 (0.014, 0.303)		0 (0, 0)		0 (0, 0.056)		0.102 (0.068, 0.136)		0.073 (0.015, 0.154)
	Hormone_therapies	count		9		9		9		9		9		9		9		9
		time		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)
		n		5 (4, 16)		14 (5, 31)		3 (1, 7)		2 (1, 4)		5 (4, 10)		4 (2, 11)		2 (0, 5)		4 (1, 13)
		post_p		0.7 (0.56, 0.81)		0.85 (0.67, 0.96)		0.75 (0.51, 0.82)		0.64 (0.57, 0.68)		0.79 (0.53, 0.91)		0.65 (0.54, 0.72)		0.68 (0.56, 0.81)		0.77 (0.6, 0.93)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.089 (0.058, 0.12)		0.089 (0.067, 0.127)		0.045 (0, 0.091)		0.064 (0, 0.15)		0.06 (0.023, 0.119)		0.084 (0, 0.105)		0.028 (0, 0.083)		0.073 (0.024, 0.215)
	Niraparib	count		11		11		11		11		11		11		11		11
		time		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)
		n		3 (1, 5)		5 (4, 8)		4 (2, 14)		4 (3, 7)		2 (2, 4)		3 (0, 7)		3 (1, 4)		4 (2, 5)
		post_p		0.54 (0.52, 0.7)		0.74 (0.52, 0.88)		0.61 (0.51, 0.74)		0.66 (0.51, 0.86)		0.63 (0.51, 0.7)		0.62 (0.57, 0.85)		0.64 (0.55, 0.87)		0.77 (0.54, 0.84)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.067 (0, 0.183)		0.083 (0.045, 0.16)		0.08 (0, 0.139)		0.106 (0.038, 0.172)		0 (0, 0.16)		0.092 (0, 0.193)		0.027 (0, 0.176)		0.072 (0, 0.095)
TP53- & AR-	Carboplatin	count	22	22			22	22
		time	15 (12, 31)	15 (12, 31)			15 (12, 31)	15 (12, 31)
		n	20 (10, 57)	4 (2, 13)			8 (3, 17)	6 (3, 12)
		post_p	0.78 (0.72, 0.9)	0.72 (0.51, 0.91)			0.73 (0.57, 0.87)	0.73 (0.56, 0.9)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.088 (0.049, 0.113)	0.065 (0, 0.139)			0.084 (0.054, 0.111)	0.079 (0.033, 0.137)
	Hormone_therapies	count	56	56			56	56
		time	10 (7, 20)	10 (7, 20)			10 (7, 20)	10 (7, 20)
		n	26 (20, 48)	4 (2, 8)			1 (0, 5)	2 (0, 6)
		post_p	0.8 (0.73, 0.92)	0.69 (0.53, 0.83)			0.6 (0.52, 0.73)	0.6 (0.52, 0.81)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.083 (0.059, 0.107)	0.069 (0, 0.125)			0 (0, 0.094)	0 (0, 0.098)
	Niraparib	count	32	32			32	32
		time	15 (10, 26)	15 (10, 26)			15 (10, 26)	15 (10, 26)
		n	20 (12, 40)	4 (1, 6)			6 (4, 11)	6 (4, 10)
		post_p	0.79 (0.74, 0.9)	0.64 (0.54, 0.79)			0.77 (0.54, 0.92)	0.73 (0.57, 0.85)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.07 (0.032, 0.097)	0.032 (0, 0.113)			0.055 (0, 0.11)	0.07 (0.026, 0.119)
	Taxel_therapies	count	31	31			31	31
		time	13 (9, 24)	13 (9, 24)			13 (9, 24)	13 (9, 24)
		n	24 (17, 45)	5 (2, 16)			3 (0, 5)	3 (1, 8)
		post_p	0.8 (0.73, 0.94)	0.72 (0.54, 0.88)			0.66 (0.53, 0.81)	0.61 (0.52, 0.76)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.072 (0.045, 0.1)	0.081 (0, 0.142)			0 (0, 0.104)	0 (0, 0.099)
TP53+	Carboplatin	count			12	12			12	12			12	12			12	12
		time			12 (9, 27)	12 (9, 27)			12 (9, 27)	12 (9, 27)			12 (9, 27)	12 (9, 27)			12 (9, 27)	12 (9, 27)
		n			10 (4, 38)	6 (2, 17)			3 (1, 6)	2 (0, 6)			4 (1, 11)	3 (1, 5)			4 (1, 5)	2 (0, 5)
		post_p			0.82 (0.62, 0.94)	0.79 (0.54, 0.9)			0.72 (0.59, 0.91)	0.64 (0.58, 0.85)			0.74 (0.52, 0.83)	0.6 (0.52, 0.78)			0.71 (0.58, 0.85)	0.72 (0.6, 0.88)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.089 (0.039, 0.114)	0.064 (0, 0.107)			0.033 (0, 0.075)	0.059 (0, 0.148)			0.073 (0, 0.112)	0.069 (0, 0.158)			0.058 (0, 0.147)	0.063 (0, 0.091)
	Hormone_therapies	count			34	34			34	34			34	34			34	34
		time			10 (8, 20)	10 (8, 20)			10 (8, 20)	10 (8, 20)			10 (8, 20)	10 (8, 20)			10 (8, 20)	10 (8, 20)
		n			16 (9, 28)	9 (5, 17)			2 (0, 4)	1 (0, 3)			3 (0, 6)	3 (0, 7)			1 (0, 3)	1 (0, 5)
		post_p			0.82 (0.72, 0.95)	0.79 (0.65, 0.92)			0.58 (0.51, 0.79)	0.64 (0.55, 0.74)			0.63 (0.56, 0.86)	0.68 (0.54, 0.9)			0.6 (0.57, 0.7)	0.55 (0.5, 0.81)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.088 (0.052, 0.131)	0.084 (0.037, 0.141)			0 (0, 0.144)	0 (0, 0.154)			0.067 (0, 0.122)	0.076 (0, 0.123)			0 (0, 0.156)	0 (0, 0.138)
	Niraparib	count			29	29			29	29			29	29			29	29
		time			13 (8, 32)	13 (8, 32)			13 (8, 32)	13 (8, 32)			13 (8, 32)	13 (8, 32)			13 (8, 32)	13 (8, 32)
		n			11 (5, 37)	5 (3, 14)			3 (1, 6)	4 (1, 9)			4 (1, 5)	3 (0, 9)			4 (0, 8)	4 (2, 8)
		post_p			0.8 (0.58, 0.96)	0.73 (0.56, 0.87)			0.71 (0.56, 0.9)	0.67 (0.51, 0.83)			0.69 (0.53, 0.9)	0.71 (0.59, 0.86)			0.73 (0.54, 0.92)	0.74 (0.55, 0.93)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.085 (0.03, 0.111)	0.081 (0, 0.128)			0.087 (0, 0.171)	0.073 (0, 0.16)			0.051 (0, 0.123)	0.072 (0, 0.147)			0.075 (0, 0.134)	0.067 (0, 0.104)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)
		n	3 (3, 3)	0 (0, 0)	2 (2, 2)	1 (1, 1)	5 (5, 5)	8 (8, 8)	1 (1, 1)	0 (0, 0)	1 (1, 1)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)	3 (3, 3)	1 (1, 1)	2 (2, 2)
		post_p	0.27 (0.27, 0.27)	NA (NA, NA)	0.39 (0.39, 0.39)	0.27 (0.27, 0.27)	0.16 (0.16, 0.16)	0.45 (0.45, 0.45)	0.25 (0.25, 0.25)	NA (NA, NA)	0.34 (0.34, 0.34)	NA (NA, NA)	0.24 (0.24, 0.24)	NA (NA, NA)	NA (NA, NA)	0.35 (0.35, 0.35)	0.44 (0.44, 0.44)	0.32 (0.32, 0.32)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.322 (0.322, 0.322)	NA (NA, NA)	0.206 (0.206, 0.206)	2.238 (2.238, 2.238)	0.074 (0.074, 0.074)	0.201 (0.201, 0.201)	2.036 (2.036, 2.036)	NA (NA, NA)	1.442 (1.442, 1.442)	NA (NA, NA)	0.2 (0.2, 0.2)	NA (NA, NA)	NA (NA, NA)	0.294 (0.294, 0.294)	0.249 (0.249, 0.249)	0.369 (0.369, 0.369)
	Hormone_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)
		n	13 (9, 15)	1 (0, 4)	8 (7, 12)	3 (1, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (0, 3)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.46 (0.19, 0.48)	0.39 (0.3, 0.47)	0.44 (0.37, 0.48)	0.46 (0.34, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.37 (0.37, 0.37)	0.48 (0.48, 0.48)	0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.055 (0.053, 0.215)	0.058 (0.012, 0.104)	0.214 (0.139, 0.286)	0.137 (0.027, 0.265)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.118 (0.024, 0.212)	0 (0, 0)	0.492 (0.492, 0.492)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23
		time	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)
		n	11 (3, 41)	3 (1, 9)	5 (3, 10)	8 (4, 13)	2 (0, 8)	1 (0, 4)	2 (0, 3)	1 (0, 4)	5 (1, 11)	4 (1, 9)	3 (1, 13)	3 (2, 9)	1 (0, 5)	1 (0, 7)	2 (0, 4)	1 (0, 3)
		post_p	0.28 (0.09, 0.44)	0.26 (0.16, 0.43)	0.21 (0.08, 0.45)	0.26 (0.04, 0.46)	0.34 (0.23, 0.45)	0.41 (0.18, 0.48)	0.28 (0.21, 0.42)	0.28 (0.08, 0.45)	0.35 (0.21, 0.41)	0.32 (0.15, 0.48)	0.33 (0.08, 0.46)	0.3 (0.16, 0.46)	0.36 (0.23, 0.47)	0.36 (0.26, 0.5)	0.4 (0.29, 0.49)	0.3 (0.21, 0.43)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.142 (0.113, 0.785)	0.258 (0.127, 0.583)	0.271 (0.161, 0.527)	0.216 (0.163, 0.546)	0.163 (0.12, 0.786)	0.168 (0, 0.288)	0.309 (0.194, 0.683)	0.304 (0.173, 0.77)	0.179 (0.117, 0.47)	0.166 (0.102, 0.436)	0.292 (0.153, 1.058)	0.271 (0.106, 0.678)	0.279 (0.133, 1.477)	0.163 (0.103, 0.406)	0.189 (0.089, 0.98)	0.253 (0.106, 1.298)
DRD+	Carboplatin	count					10	10	10	10					10	10	10	10
		time					16 (8, 28)	16 (8, 28)	16 (8, 28)	16 (8, 28)					16 (8, 28)	16 (8, 28)	16 (8, 28)	16 (8, 28)
		n					6 (3, 12)	4 (2, 8)	4 (2, 4)	4 (3, 7)					3 (2, 9)	4 (2, 6)	2 (1, 5)	3 (1, 6)
		post_p					0.29 (0.17, 0.46)	0.44 (0.36, 0.48)	0.42 (0.2, 0.5)	0.34 (0.23, 0.46)					0.4 (0.18, 0.47)	0.36 (0.14, 0.44)	0.33 (0.28, 0.41)	0.39 (0.24, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.17 (0.107, 0.299)	0.149 (0.131, 0.238)	0.208 (0.121, 0.441)	0.202 (0.112, 0.326)					0.167 (0.092, 0.444)	0.219 (0.045, 0.378)	0.584 (0.114, 0.839)	0.191 (0.144, 2.067)
	Hormone_therapies	count					9	9	9	9					9	9	9	9
		time					30 (23, 34)	30 (23, 34)	30 (23, 34)	30 (23, 34)					30 (23, 34)	30 (23, 34)	30 (23, 34)	30 (23, 34)
		n					2 (0, 5)	4 (0, 10)	6 (2, 14)	3 (2, 6)					4 (1, 6)	5 (3, 8)	3 (2, 10)	3 (1, 6)
		post_p					0.36 (0.1, 0.41)	0.37 (0.31, 0.46)	0.42 (0.18, 0.47)	0.42 (0.29, 0.48)					0.42 (0.27, 0.45)	0.41 (0.24, 0.48)	0.36 (0.33, 0.43)	0.35 (0.19, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.237 (0.157, 0.553)	0.146 (0.132, 0.306)	0.156 (0.105, 0.316)	0.2 (0.144, 0.29)					0.153 (0.096, 0.51)	0.162 (0.115, 0.266)	0.163 (0.138, 0.286)	0.219 (0.136, 0.302)
	Niraparib	count					5	5	5	5					5	5	5	5
		time					21 (17, 28)	21 (17, 28)	21 (17, 28)	21 (17, 28)					21 (17, 28)	21 (17, 28)	21 (17, 28)	21 (17, 28)
		n					2 (1, 11)	6 (5, 16)	3 (1, 5)	4 (3, 6)					3 (2, 5)	4 (3, 15)	3 (2, 7)	1 (1, 4)
		post_p					0.32 (0.12, 0.35)	0.32 (0.18, 0.44)	0.33 (0.17, 0.42)	0.38 (0.14, 0.46)					0.29 (0.21, 0.35)	0.43 (0.24, 0.44)	0.48 (0.28, 0.49)	0.37 (0.28, 0.42)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.294 (0.17, 0.973)	0.122 (0.097, 0.198)	0.238 (0.147, 0.458)	0.249 (0.125, 0.365)					0.211 (0.154, 0.278)	0.139 (0.131, 0.273)	0.196 (0.123, 0.642)	0.335 (0.21, 0.895)
	Taxel_therapies	count					60	60	60	60					60	60	60	60
		time					29 (22, 34)	29 (22, 34)	29 (22, 34)	29 (22, 34)					29 (22, 34)	29 (22, 34)	29 (22, 34)	29 (22, 34)
		n					5 (2, 13)	5 (2, 11)	2 (1, 6)	2 (1, 5)					4 (1, 7)	4 (1, 8)	2 (1, 5)	2 (0, 5)
		post_p					0.34 (0.16, 0.45)	0.35 (0.13, 0.47)	0.34 (0.21, 0.43)	0.32 (0.15, 0.43)					0.36 (0.19, 0.48)	0.36 (0.22, 0.48)	0.35 (0.21, 0.46)	0.34 (0.21, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.158 (0.113, 0.413)	0.159 (0.104, 0.348)	0.294 (0.163, 0.786)	0.294 (0.168, 0.885)					0.165 (0.106, 0.573)	0.178 (0.112, 0.664)	0.265 (0.15, 1.697)	0.306 (0.169, 1.229)
TEfus+	Carboplatin	count		8		8		8		8		8		8		8		8
		time		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)
		n		3 (1, 5)		6 (3, 16)		4 (3, 9)		3 (1, 4)		4 (3, 11)		3 (2, 6)		4 (3, 6)		3 (1, 6)
		post_p		0.23 (0.19, 0.36)		0.38 (0.25, 0.49)		0.44 (0.21, 0.49)		0.32 (0.21, 0.44)		0.39 (0.33, 0.47)		0.41 (0.29, 0.47)		0.35 (0.2, 0.46)		0.36 (0.3, 0.44)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.252 (0.162, 1.371)		0.163 (0.119, 0.338)		0.125 (0.082, 0.206)		0.249 (0.183, 0.474)		0.122 (0.098, 0.336)		0.2 (0.149, 0.489)		0.147 (0.127, 0.341)		0.196 (0.132, 0.929)
	Hormone_therapies	count		3		3		3		3		3		3		3		3
		time		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)
		n		4 (2, 7)		11 (5, 13)		4 (1, 9)		3 (1, 3)		4 (3, 5)		4 (3, 6)		3 (1, 4)		3 (1, 7)
		post_p		0.33 (0.29, 0.37)		0.41 (0.28, 0.46)		0.46 (0.45, 0.46)		0.34 (0.23, 0.46)		0.33 (0.29, 0.39)		0.41 (0.38, 0.43)		0.32 (0.27, 0.44)		0.45 (0.29, 0.47)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.222 (0.181, 0.477)		0.142 (0.136, 0.166)		0.127 (0.112, 0.142)		0.377 (0.171, 0.776)		0.128 (0.104, 0.211)		0.135 (0.124, 0.184)		0.239 (0.15, 0.341)		0.24 (0.119, 0.703)
	Niraparib	count		5		5		5		5		5		5		5		5
		time		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)
		n		3 (2, 4)		6 (3, 22)		4 (3, 10)		2 (0, 12)		4 (3, 10)		6 (1, 11)		3 (1, 5)		3 (1, 13)
		post_p		0.38 (0.29, 0.43)		0.28 (0.21, 0.38)		0.39 (0.24, 0.44)		0.36 (0.31, 0.41)		0.35 (0.17, 0.38)		0.4 (0.4, 0.42)		0.4 (0.24, 0.49)		0.33 (0.21, 0.45)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.19 (0.122, 0.457)		0.228 (0.151, 0.42)		0.13 (0.128, 0.213)		0.377 (0.152, 0.845)		0.137 (0.111, 0.35)		0.152 (0.124, 0.195)		0.135 (0.122, 0.569)		0.251 (0.157, 0.355)
	Taxel_therapies	count		106		106		106		106		106		106		106		106
		time		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)
		n		5 (2, 13)		8 (5, 14)		4 (1, 9)		2 (0, 4)		5 (2, 10)		4 (2, 6)		2 (0, 6)		2 (0, 4)
		post_p		0.35 (0.14, 0.48)		0.18 (0.03, 0.42)		0.37 (0.2, 0.48)		0.36 (0.2, 0.45)		0.36 (0.18, 0.48)		0.3 (0.14, 0.45)		0.37 (0.21, 0.48)		0.34 (0.21, 0.45)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.165 (0.098, 0.35)		0.233 (0.168, 0.477)		0.167 (0.102, 0.42)		0.304 (0.165, 1.175)		0.157 (0.092, 0.369)		0.233 (0.146, 0.686)		0.217 (0.105, 0.789)		0.293 (0.161, 1.123)
TP53- & AR-	Carboplatin	count	109	109			109	109
		time	21 (13, 31)	21 (13, 31)			21 (13, 31)	21 (13, 31)
		n	19 (7, 52)	4 (1, 8)			6 (3, 13)	6 (3, 12)
		post_p	0.32 (0.11, 0.47)	0.36 (0.16, 0.48)			0.34 (0.15, 0.48)	0.36 (0.16, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.131 (0.105, 0.18)	0.186 (0.103, 0.541)			0.147 (0.096, 0.349)	0.149 (0.095, 0.361)
	Hormone_therapies	count	145	145			145	145
		time	13 (7, 28)	13 (7, 28)			13 (7, 28)	13 (7, 28)
		n	23 (16, 47)	4 (2, 10)			2 (0, 7)	2 (0, 8)
		post_p	0.3 (0.11, 0.45)	0.35 (0.16, 0.48)			0.36 (0.23, 0.49)	0.37 (0.22, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.13 (0.105, 0.178)	0.173 (0.102, 0.41)			0.194 (0.087, 0.678)	0.196 (0.107, 0.586)
	Niraparib	count	131	131			131	131
		time	23 (13, 31)	23 (13, 31)			23 (13, 31)	23 (13, 31)
		n	16 (7, 55)	4 (2, 11)			7 (3, 13)	6 (2, 13)
		post_p	0.3 (0.1, 0.47)	0.36 (0.17, 0.48)			0.34 (0.14, 0.48)	0.34 (0.15, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.134 (0.108, 0.205)	0.169 (0.114, 0.554)			0.142 (0.099, 0.349)	0.156 (0.09, 0.409)
	Taxel_therapies	count	121	121			121	121
		time	21 (13, 31)	21 (13, 31)			21 (13, 31)	21 (13, 31)
		n	20 (9, 55)	6 (2, 12)			4 (2, 11)	4 (1, 9)
		post_p	0.3 (0.1, 0.46)	0.35 (0.14, 0.48)			0.37 (0.18, 0.48)	0.37 (0.2, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.13 (0.109, 0.219)	0.163 (0.097, 0.402)			0.156 (0.101, 0.363)	0.19 (0.107, 0.519)
TP53+	Carboplatin	count			3	3			3	3			3	3			3	3
		time			17 (15, 28)	17 (15, 28)			17 (15, 28)	17 (15, 28)			17 (15, 28)	17 (15, 28)			17 (15, 28)	17 (15, 28)
		n			7 (6, 8)	9 (6, 18)			2 (1, 3)	5 (3, 5)			5 (1, 6)	3 (1, 4)			1 (1, 2)	4 (2, 7)
		post_p			0.41 (0.37, 0.42)	0.45 (0.31, 0.46)			0.44 (0.37, 0.46)	0.45 (0.32, 0.48)			0.37 (0.33, 0.4)	0.42 (0.37, 0.43)			0.35 (0.29, 0.36)	0.37 (0.32, 0.43)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.158 (0.147, 0.17)	0.18 (0.147, 0.252)			0.137 (0.089, 0.476)	0.197 (0.101, 0.383)			0.129 (0.121, 0.137)	0.2 (0.159, 0.242)			0.493 (0.296, 0.655)	0.201 (0.197, 0.847)
	Hormone_therapies	count			4	4			4	4			4	4			4	4
		time			11 (9, 12)	11 (9, 12)			11 (9, 12)	11 (9, 12)			11 (9, 12)	11 (9, 12)			11 (9, 12)	11 (9, 12)
		n			16 (15, 17)	4 (3, 4)			1 (0, 3)	1 (0, 2)			1 (0, 4)	2 (2, 3)			2 (1, 2)	2 (0, 4)
		post_p			0.36 (0.16, 0.49)	0.3 (0.12, 0.44)			0.5 (0.5, 0.5)	0.35 (0.31, 0.42)			0.44 (0.42, 0.46)	0.4 (0.25, 0.47)			0.32 (0.22, 0.41)	0.27 (0.23, 0.4)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.151 (0.102, 0.179)	0.243 (0.143, 0.379)			0.074 (0.015, 0.133)	0.687 (0.282, 0.838)			0.165 (0.148, 0.182)	0.162 (0.112, 0.307)			0.22 (0.049, 1.008)	0.819 (0.247, 4.35)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			20 (20, 20)	20 (20, 20)			20 (20, 20)	20 (20, 20)			20 (20, 20)	20 (20, 20)			20 (20, 20)	20 (20, 20)
		n			6 (6, 6)	7 (7, 7)			6 (6, 6)	4 (4, 4)			3 (3, 3)	2 (2, 2)			2 (2, 2)	2 (2, 2)
		post_p			0.24 (0.24, 0.24)	0.44 (0.44, 0.44)			0.44 (0.44, 0.44)	0.36 (0.36, 0.36)			0.49 (0.49, 0.49)	0.25 (0.25, 0.25)			0.26 (0.26, 0.26)	0.41 (0.41, 0.41)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.176 (0.176, 0.176)	0.188 (0.188, 0.188)			0.11 (0.11, 0.11)	0.202 (0.202, 0.202)			0.136 (0.136, 0.136)	0.291 (0.291, 0.291)			0.348 (0.348, 0.348)	0.19 (0.19, 0.19)
	Taxel_therapies	count			366	366			366	366			366	366			366	366
		time			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)
		n			7 (4, 14)	8 (5, 15)			2 (0, 5)	2 (0, 5)			4 (2, 8)	4 (2, 8)			2 (0, 5)	2 (0, 5)
		post_p			0.2 (0.07, 0.41)	0.17 (0.04, 0.42)			0.34 (0.2, 0.47)	0.35 (0.2, 0.47)			0.29 (0.11, 0.45)	0.28 (0.13, 0.47)			0.35 (0.19, 0.47)	0.34 (0.21, 0.47)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.246 (0.16, 0.45)	0.249 (0.162, 0.49)			0.292 (0.139, 0.991)	0.272 (0.137, 1.198)			0.268 (0.152, 0.723)	0.255 (0.141, 0.729)			0.28 (0.142, 1.205)	0.287 (0.143, 1.245)